Neurological Conditions

Shape Divider 1
Posted on Thursday January 21, 2021

Selected peer reviewed published research on Neurological Conditions:

There are several neurological conditions that may affect the visual pathway from the optic nerve head to the visual cortex resulting in vision loss or even blindness. Electroretinograms (ERGs) and visual evoked potentials (VEP) are useful in clinical diagnosis as well as evaluating the severity of optic neurological conditions.


Robson AG, Nilsson J, Li S, et al. ISCEV guide to visual electrodiagnostic procedures. Springer 2018;136:1-26.


Constable PA, Gaigg SB, Bowler DM, et al. Full-field electroretinogram in autism spectrum disorder. Doc Ophthalmol 2016; 132:83–99.

Brain Tumors

Hidajat RR, McLay JL, Goode DH, Hidayat JR. The value of VEP in the diagnosis and post-operative monitoring of meningioma. Doc Ophthalmol 2006; 113:165-169.

Holder, GE. The Effects of chiasmal compression on the pattern visual evoked potential.
Electroencephalogr Clin Neurophysiol 1978; 45:278-280.

North K, Cochineas C, Tang E, Fagan E. Optic gliomas in neuro-fibromatosis type 1: role of visual evoked potentials. Pediatr Neurol 1994;10:117-23.

Wolsey DH, Larson SA, Creel D, Hoffman R. Can screening for optic nerve gliomas in patients with neurofibromatosis type I be performed with visual-evoked potential testing? J AAPOS, 2006; 10(4): 307-311.

Idiopathic Intracranial Hypertension

Park JC, Moss HE, McAnany JJ. Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response. Doc Ophthalmol 2018 February; 136(1): 45-55.

Leber’s Hereditary Optic Neuropathy

Karanjia R, Berezovsky A, Sacai PY, et al. The photopic negative response: an objective measure of retinal ganglion cell function in patients with Leber’s hereditary optic neuropathy. Invest Ophthalmol Vis Sci. 2017;58:BIO300–BIO306.

Non-Organic Vision Loss

Bach M, Farmer JD. Evaluation of the “Freiburg Acuity VEP” on commercial equipment. Doc Ophthalmol 2020; 140:139-145.

Bach M, Maurer JP, Wolf ME. Visual evoked potential-based acuity assessment in normal vision, artificially degraded vision, and in patients. Br J Ophthalmol 2008; 92:396-403.

Optic Neuritis

Celesia GC, Kaufman D, Cone SB. Simultaneous recording of pattern electroretinography and visual evoked potentials in multiple sclerosis: a method to separate demyelination from axonal damage to the optic nerve. Arch Neurol 1986; 43:1247-1252.

Cox TA, Thompson HS, Hayreh SS, Snyder JE. Visual evoked potential and pupillary signs: a comparison in optic nerve disorder. Arch Ophthalmol 1982; 100:1603-1607.

Holder GE. Electrophysiological assessment of optic nerve disease. Eye 2004; 18:1133–1143.

Matthews WB, Small DG, Small M, Pountney E. Pattern reversal evoked visual potential in the diagnosis of multiple sclerosis. J Neurol Neurosurg Psychiatry 1977; 40:1009-1014.

Yap GH, Chen LY, Png R et al. Clinical value of electrophysiology in determining
the diagnosis of visual dysfunction in neuro-ophthalmology patients. Doc Ophthalmol 2015; 131:189–196.

You Y, Gupta VK, Li JC, et al. Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss. Rev Neurosci. 2013; 24(3): 301–321

Schizophrenia and Bipolar Disorder

Hébert M, Mérette C, Gagné AM, et al. The electroretinogram may differentiate schizophrenia from bipolar disorder. Bio Psychiatry 2019;87(3): 263-270.

Traumatic Brain Injury

De Beaumont L, Brisson B, Lassonde M, Jolicoeur P. Long-term electrophysiological changes in athletes with a history of multiple concussions. Brain Injury 2004; 21(6):631-644.

Freed S, Fishman Hellerstein L. Visual electrodiagnostic findings in mild traumatic brain injury. Brain Injury 1997; 11(1):25-36.

Lachapelle J, Ouimet C, Bach M, et al. Texture segregation in traumatic brain injury—a VEP study. Vis Res 2004; 44:2835-2842.

Laskowski RA, Creed JA, Raghupathi R. Chapter 4 Pathophysiology of mild TBI Implications for altered signaling pathways.

Samo S. Erasmus LP, Lippert G, et al. Electrophysiological correlates of visual impairments after traumatic brain injury. Vis Res 2000; 40:3029-3038.