Reference Articles

  • Preclinical Publications

    The following references peer-reviewed journal publications for which data was collected using Celeris, the Diagnosys preclinical visual electrophysiology system. The papers are listed in reverse chronological order. You may suggest adding a paper to this list using the form below. 2024 Mice | Full-field ERG intensity series | Micro RNAs Du SW, Komirisetty R, Lewandowski…

  • Inherited Retinal Diseases (IRD)

    Inherited retinal diseases (IRDs) are a group of clinically and genetically heterogeneous diseases, which cause visual loss due to improper development or premature death of the retinal photoreceptors. IRDs affect individuals of all ages, with different IRDs progressing at different rates. Many IRDs are degenerative, getting worse over time and causing severe vision loss or…

  • Electrodes for Clinical Practice

    Key Topics Active electrodes record the signal from the stimulated region, reference electrodes record ambient noise, and the ground electrode serves as the zero reference for the positive or negative polarity of the signal. Comparison of commonly used ERG active electrodes for signal amplitude (specifically signal to noise ratio) and patient comfort. Limited options for…

  • Pediatric Conditions

    There are several pediatric disorders that may cause vision loss or blindness in children due to retinal, visual pathway, or cortical pathology. The objective data obtained by electroretinograms, electrooculargrams, and visual evoked potentials are an integral part to the diagnosis and monitoring of infants and children either with or suspected of having visual impairment.  …

  • Neurological Conditions

    There are several neurological conditions that may affect the visual pathway from the optic nerve head to the visual cortex resulting in vision loss or even blindness. Electroretinograms (ERGs) and visual evoked potentials (VEP) are useful in clinical diagnosis as well as evaluating the severity of optic neurological conditions.   References Robson AG, Nilsson J,…

  • Age-Related Macular Degeneration (AMD)

    Summary of select, peer reviewed published research on age related macular degeneration: Age-related macular degeneration (AMD) is a common eye disease that is the leading cause of vision loss for people over 50 years of age. There are two versions of AMD, dry and wet.

  • Diabetic Retinopathy

    Within the first two decades following the diagnosis of diabetes, nearly all patients with type 1 diabetes and 60% of patients with type 2 diabetes will develop diabetic retinopathy (DR). Despite better diabetes management and glycemic control, DR remains a major health concern due to an increasing number of people with diabetes. Recently, researchers have…

  • Glaucoma

    Glaucoma is a group of conditions characterized by cupping of the optic disc with corresponding visual field defects due to retinal ganglion cell (RGC) loss. In some cases, the condition can progress to the point of causing optic neuropathy. It is the most common cause of irreversible blindness worldwide and because it is a progressive…

  • Retinal Toxicity

    Hydroxychloroquine (HCQ) and its predecessor, chloroquine (CQ) are antimalarial drugs with well-established benefits for treating rheumatoid arthritis, lupus and other connective tissue and skin disorders. Extensive research has shown long-term usage of either drug to be associated with retinal toxicity. Early detection of HCQ/CQ retinopathy is imperative to minimize the risk of any associated vision…