The following references peer-reviewed journal publications for which data was collected using Celeris, the Diagnosys preclinical visual electrophysiology system. The papers are listed in reverse chronological order. You may suggest adding a paper to this list using the form below.
2024
Mice | Full-field ERG intensity series | Micro RNAs
Du SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 Jun;300(6):107344. doi: 10.1016/j.jbc.2024.107344. Epub 2024 May 4. PMID: 38705389; PMCID: PMC11140208.
Mice | PERG, Full-field ERG | Glaucoma
Lin F, Li Y, Wang J, Jardines S, King R, Chrenek MA, Wiggs JL, Boatright JH, Geisert EE. POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells. Sci Rep. 2024 May 2;14(1):10096. doi: 10.1038/s41598-024-60444-5. PMID: 38698014; PMCID: PMC11066091.
Rats | Full-field ERG | Exudative age-related macular degeneration (eAMD)
Xu L, Prentice JR, Velez-Montoya R, Sinha A, Barakat MR, Gupta A, Lowenthal R, Khanani AM, Kaiser PK, Heier JS, Jones A, Morgenstern JL, Strong Caldwell A, Mueller N, Quiroz-Mercado H, Huvard M, Olson JL, Bhatt R, Bhandari R. Bispecific VEGF-A and Angiopoietin-2 Antagonist RO-101 Preclinical Efficacy in Model of Neovascular Eye Disease. Ophthalmol Sci. 2024 Jan 18;4(4):100467. doi: 10.1016/j.xops.2024.100467. PMID: 38591047; PMCID: PMC11000112.
2023
Rats | Flash VEP; full-field ERG | Ischemic optic neuropathy
Chien JY, Ciou JW, Yen Y, Huang SP. Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway. Biomed Pharmacother. 2023 Dec 31;169:115861. doi: 10.1016/j.biopha.2023.115861. Epub 2023 Nov 14. PMID: 37972470.
Rats | Full-field ERG, including C-wave | ERG methods
Feola AJ, Allen RS, Chesler KC, Pardue MT. Development of an Automated Electroretinography Analysis Approach. Transl Vis Sci Technol. 2023 Nov 1;12(11):14. doi: 10.1167/tvst.12.11.14. PMID: 37943551; PMCID: PMC10637214.
Mice | mfERG, full-field ERG including C-waves | Leber congenital amaurosis 16 (LCA16); gene editing
Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha K, Pattnaik BR. Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy. J Clin Invest. 2023 Oct 2;133(19):e171356. doi: 10.1172/JCI171356. PMID: 37561581; PMCID: PMC10541187.
Mice | Full-field ERG | Matthew–Wood syndrome (MWS); vitamin A deficiency
Yan Z, Yao Y, Li L, Cai L, Zhang H, Zhang S, Xiao Q, Wang X, Zuo E, Xu C, Wu J, Yang H. Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice. Mol Ther Nucleic Acids. 2023 Aug 7;33:750-761. doi: 10.1016/j.omtn.2023.08.002. PMID: 37621413; PMCID: PMC10445100.
Rats | Full-field ERG | Glaucoma
Nordahl KML, Fedulov V, Holm A, Haanes KA. Intraocular Adeno-Associated Virus-Mediated Transgene Endothelin-1 Delivery to the Rat Eye Induces Functional Changes Indicative of Retinal Ischemia-A Potential Chronic Glaucoma Model. Cells. 2023 Aug 2;12(15):1987. doi: 10.3390/cells12151987. PMID: 37566067; PMCID: PMC10417058.
Mice | Full-field ERG including C-waves | Rod-cone dystrophies (RCDs) and cone-rod dystrophies (CRDs)
García-Llorca A, Ólafsson KH, Sigurdsson AT, Eysteinsson T. Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitfmi/+ Mice. Genes (Basel). 2023 Jul 17;14(7):1458. doi: 10.3390/genes14071458. PMID: 37510362; PMCID: PMC10379086.
Mice | Full-field ERG intensity series | Alzheimer disease
Sugasini D, Park JC, McAnany JJ, Kim TH, Ma G, Yao X, Antharavally B, Oroskar A, Oroskar AA, Layden BT, Subbaiah PV. Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA. Sci Rep. 2023 Jun 6;13(1):9179. doi: 10.1038/s41598-023-36268-0. PMID: 37280266; PMCID: PMC10244360.
Mice | Full-field ERG | Normal aging
Park JC, Persidina O, Balasubramanian G, Nguyen T, Pradeep A, Hetling JR, McAnany JJ. Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography. Sci Rep. 2023 May 31;13(1):8860. doi: 10.1038/s41598-023-35996-7. PMID: 37258636; PMCID: PMC10232421.
Mice | Full-field ERG | Matthew–Wood syndrome (MWS); vitamin A deficiency
Moon J, Zhou G, Jankowsky E, von Lintig J. Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium. PNAS Nexus. 2023 May 19;2(6):pgad167. doi: 10.1093/pnasnexus/pgad167. PMID: 37275262; PMCID: PMC10235913.
Mice | Full-field ERG | ERG methods
Liu S, Yuan F, Xiang M. Comparative analysis of electroretinogram with subdermal and invasive recording methods in mice. Biochem Biophys Res Commun. 2023 May 7;655:118-126. doi: 10.1016/j.bbrc.2023.03.029. Epub 2023 Mar 11. PMID: 36934587.
Mice | Full-field ERG, including C-wave | Excessive exposure to blue light
Chan YJ, Hsiao G, Wan WN, Yang TM, Tsai CH, Kang JJ, Lee YC, Fang TC, Cheng YW, Li CH. Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17. Fluids Barriers CNS. 2023 Apr 24;20(1):31. doi: 10.1186/s12987-023-00430-7. PMID: 37095509; PMCID: PMC10124034.
Rats | Full-field ERG; PhNR | Optic neuropathy; RGC
Pacwa A, Machowicz J, Akhtar S, Rodak P, Liu X, Pietrucha-Dutczak M, Lewin-Kowalik J, Amadio M, Smedowski A. Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells. Front Cell Neurosci. 2023 Feb 17;17:1131356. doi: 10.3389/fncel.2023.1131356. PMID: 36874215; PMCID: PMC9982123.
Mice | Full-field ERG, flash VEP, PhNR | Alzheimer’s disease and frontotemporal dementia
Parka A, Volbracht C, Hall B, Bastlund JF, Nedergaard M, Laursen B, Botta P, Sotty F. Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model. J Alzheimers Dis. 2023;93(1):247-262. doi: 10.3233/JAD-220964. PMID: 37005884.
2022
Mice | PERG | Aging and glaucoma
Li S, Jakobs TC. Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma. Cell Rep. 2022 Dec 27;41(13):111880. doi: 10.1016/j.celrep.2022.111880. PMID: 36577373; PMCID: PMC9847489.
Mice | Full-field ERG | White noise stimuli
Stallwitz N, Joachimsthaler A, Kremers J. Luminance white noise electroretinograms (wnERGs) in mice. Front Neurosci. 2022 Dec 9;16:1075126. doi: 10.3389/fnins.2022.1075126. PMID: 36570850; PMCID: PMC9780692.
Mice | PERG | Trauma, hypoxia, inflammation, glaucoma
Tan Z, Guo Y, Shrestha M, Sun D, Gregory-Ksander M, Jakobs TC. Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109273. doi: 10.1016/j.exer.2022.109273. Epub 2022 Oct 4. PMID: 36206859; PMCID: PMC10970711.
Mice | Full-field ERG | CLN7 Batten disease
Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ. Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics. EBioMedicine. 2022 Nov;85:104314. doi: 10.1016/j.ebiom.2022.104314. Epub 2022 Oct 29. PMID: 36374771; PMCID: PMC9626557.
Rats | Full-field ERG; PhNR | Glaucoma, ischemic optic neuropathy and retinopathy, age-related macular degeneration, and diabetic retinopathy
Olakowska E, Rodak P, Pacwa A, Machowicz J, Machna B, Lewin-Kowalik J, Smedowski A. Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy. Cells. 2022 Sep 29;11(19):3062. doi: 10.3390/cells11193062. PMID: 36231022; PMCID: PMC9564175.
Mice | Full-field ERG | Bardet Biedl Syndrome
Mayer SK, Thomas J, Helms M, Kothapalli A, Cherascu I, Salesevic A, Stalter E, Wang K, Datta P, Searby C, Seo S, Hsu Y, Bhattarai S, Sheffield VC, Drack AV. Progressive retinal degeneration of rods and cones in a Bardet-Biedl syndrome type 10 mouse model. Dis Model Mech. 2022 Sep 1;15(9):dmm049473. doi: 10.1242/dmm.049473. Epub 2022 Sep 20. PMID: 36125046; PMCID: PMC9536196.
Mice | Full-field ERG | Phospholipase D isoforms 1 and 2 in the mammalian brain and retina
Barber CN, Goldschmidt HL, Lilley B, Bygrave AM, Johnson RC, Huganir RL, Zack DJ, Raben DM. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. J Lipid Res. 2022 Aug;63(8):100247. doi: 10.1016/j.jlr.2022.100247. Epub 2022 Jun 25. PMID: 35764123; PMCID: PMC9305353.
Mice | Full-field ERG | Spinocerebellar ataxia type 3
Toulis V, Casaroli-Marano R, Camós-Carreras A, Figueras-Roca M, Sánchez-Dalmau B, Muñoz E, Ashraf NS, Ferreira AF, Khan N, Marfany G, Costa MDC. Altered retinal structure and function in Spinocerebellar ataxia type 3. Neurobiol Dis. 2022 Aug;170:105774. doi: 10.1016/j.nbd.2022.105774. Epub 2022 May 21. PMID: 35605759.
Mice | Full-field ERG intensity series; including UV stimulus | Retinitis Pigmentosa
Leinonen H, Lyon DC, Palczewski K, Foik AT. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 Jun 27;9(3):ENEURO.0107-22.2022. doi: 10.1523/ENEURO.0107-22.2022. PMID: 35701168; PMCID: PMC9239850.
Mice | Full-field ERG intensity series | Rod-Cone interactions; lots of ERG data
Lankford CK, Umino Y, Poria D, Kefalov V, Solessio E, Baker SA. Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1. J Neurosci. 2022 May 25;42(21):4231-4249. doi: 10.1523/JNEUROSCI.2271-21.2022. Epub 2022 Apr 18. PMID: 35437278; PMCID: PMC9145265.
Mice | flash VEP | VEP optimization
Liu S, Xiang K, Lei Q, Qiu S, Xiang M, Jin K. An optimized procedure to record visual evoked potential in mice. Exp Eye Res. 2022 May;218:109011. doi: 10.1016/j.exer.2022.109011. Epub 2022 Mar 1. PMID: 35245512.
Mice | Full-field ERG intensity series; including UV stimulus | Leber congenital amaurosis (LCA)
Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3. PMID: 35383196; PMCID: PMC8983734.
Mice | PERG, full-field ERG, VEP | Glaucoma; RGC
Visuvanathan S, Baker AN, Lagali PS, Coupland SG, Miller G, Hauswirth WW, Tsilfidis C. XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma. Gene Ther. 2022 Apr;29(3-4):147-156. doi: 10.1038/s41434-021-00281-7. Epub 2021 Aug 6. PMID: 34363035.
Mice | PERG | Glaucoma
Zeng H, Dumitrescu AV, Wadkins D, Elwood BW, Gramlich OW, Kuehn MH. Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models. Biomolecules. 2022 Feb 9;12(2):281. doi: 10.3390/biom12020281. PMID: 35204782; PMCID: PMC8961625.
Mice | Full-field ERG | Cone spatiotemporal modifications with cone death
Lee JY, Care RA, Kastner DB, Della Santina L, Dunn FA. Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency. Cell Rep. 2022 Feb 1;38(5):110317. doi: 10.1016/j.celrep.2022.110317. PMID: 35108533; PMCID: PMC8865908.
Mice | Full-field ERG | Bardet Biedl Syndrome
Sara K. Mayer, Jacintha Thomas, Megan Helms, Aishwarya Kothapalli, Ioana Cherascu, Adisa Salesevic, Elliot Stalter, Kai Wang, Poppy Datta, Charles Searby, Seongjin Seo, Ying Hsu, Sajag Bhattarai, Val C. Sheffield, Arlene V. Drack. Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones. bioRxiv 2022.01.19.476952; doi: 10.1101/2022.01.19.476952
Mice | Full-field ERG | Paget disease
Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 8;20(1):21. doi: 10.1186/s12967-021-03186-6. PMID: 34998409; PMCID: PMC8742393.
Mice | PERG, full-field ERG | Alzheimer’s disease
Frame G, Schuller A, Smith MA, Crish SD, Dengler-Crish CM. Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer’s Disease Mice. J Alzheimers Dis. 2022;88(2):471-492. doi: 10.3233/JAD-220016. PMID: 35599482; PMCID: PMC9398084.
2021
Mice | Full-field ERG intensity series | Diabetes
Saadane A, Lessieur EM, Du Y, Liu H, Kern TS. Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy. PLoS One. 2020 Sep 17;15(9):e0238727. doi: 10.1371/journal.pone.0238727. PMID: 32941450; PMCID: PMC7498040.
Chicks | Full-field ERG intensity series | Glaucoma, retinal ischemia, vascular occlusion, diabetic retinopathy
Heisler-Taylor T, Wan R, Urbanski EG, Hamadmad S, Shah MH, Wilson H, Racine J, Cebulla CM. Multimodal imaging and functional analysis of the chick NMDA retinal damage model. PLoS One. 2021 Sep 7;16(9):e0257148. doi: 10.1371/journal.pone.0257148. PMID: 34492087; PMCID: PMC8423281.
Mice | Full-field ERG | RGC
Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y. Disassembly and rewiring of a mature converging excitatory circuit following injury. Cell Rep. 2021 Aug 3;36(5):109463. doi: 10.1016/j.celrep.2021.109463. PMID: 34348156; PMCID: PMC8381591.
Mice | Full-field ERG intensity series; including UV stimulus | Valosin-containing protein (VCP); musculoskeletal and neurodegenerative conditions
Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30. PMID: 33931547; PMCID: PMC8456514.
Mice | PERG | neurofibromatosis 1 (NF1) cancer
Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. 2021 Jun;594(7862):277-282. doi: 10.1038/s41586-021-03580-6. Epub 2021 May 26. PMID: 34040258; PMCID: PMC8346229.
Mice | Full-field ERG, including C-wave | RPE dysfunction; AMD, RP
Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10;6(9):e146604. doi: 10.1172/jci.insight.146604. PMID: 33784255; PMCID: PMC8262343.
Mice | Full-field ERG | Leber congenital amaurosis (LCA); CRISPR–Cas9
Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 Feb;5(2):169-178. doi: 10.1038/s41551-020-00632-6. Epub 2020 Oct 19. Erratum in: Nat Biomed Eng. 2020 Nov;4(11):1119. doi: 10.1038/s41551-020-00652-2. PMID: 33077938; PMCID: PMC7885272.
Mice | PERG | Glaucoma; RGC
Xiong S, Kumar A, Tian S, Taher EE, Yang E, Kinchington PR, Xia X, Du Y. Stem cell transplantation rescued a primary open-angle glaucoma mouse model. Elife. 2021 Jan 28;10:e63677. doi: 10.7554/eLife.63677. PMID: 33506763; PMCID: PMC7864631.
Mice | Full-field ERG; STR | Alzheimer’s disease
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, Moons L, De Groef L. The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research. Acta Neuropathol Commun. 2021 Jan 6;9(1):6. doi: 10.1186/s40478-020-01102-5. PMID: 33407903; PMCID: PMC7788955.
Guinea pigs | PERG, full-field ERG | RGC function; glaucoma; ONC
Jnawali A, Lin X, Patel NB, Frishman LJ, Ostrin LA. Retinal ganglion cell ablation in guinea pigs. Exp Eye Res. 2021 Jan;202:108339. doi: 10.1016/j.exer.2020.108339. Epub 2020 Oct 27. PMID: 33127343; PMCID: PMC7855240.
2020
Mice | Full-field ERG | pathogenesis of experimental bacterial endophthalmitis
Singh PK, Singh S, Wright RE 3rd, Rattan R, Kumar A. Aging, But Not Sex and Genetic Diversity, Impacts the Pathobiology of Bacterial Endophthalmitis. Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):5. doi: 10.1167/iovs.61.14.5. PMID: 33263715; PMCID: PMC7718809.
Mice | PERG | Ageing; regeneration in vivo; glaucoma; RGC function
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. PMID: 33268865; PMCID: PMC7752134.
Mice | Full-field ERG; pSTR; nSTR | RGC function
Mori S, Kurimoto T, Miki A, Maeda H, Kusuhara S, Nakamura M. Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival. Mol Neurobiol. 2020 Nov;57(11):4530-4548. doi: 10.1007/s12035-020-02030-0. Epub 2020 Aug 4. PMID: 32748371; PMCID: PMC7515957.
Mice | Full-field ERG intensity series | Homeostatic plasticity; RP
Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422. PMID: 32960171; PMCID: PMC7529457.
Mice | Full-field ERG intensity series | dCas9-VPR–mediated transcriptional activation of functionally equivalent genes
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. Sci Adv. 2020 Aug 19;6(34):eaba5614. doi: 10.1126/sciadv.aba5614. PMID: 32875106; PMCID: PMC7438099.
Mice | PERG, pVEP | Glaucoma; RGC
Harun-Or-Rashid M, Pappenhagen N, Zubricky R, Coughlin L, Jassim AH, Inman DM. MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma. Neurobiol Dis. 2020 Jul;141:104944. doi: 10.1016/j.nbd.2020.104944. Epub 2020 May 15. PMID: 32422282; PMCID: PMC7337244.
Mice | Full-field ERG | AMD, oxidative stress
Huang J, Liu Y, Mao K, Gu Q, Wu X. Tetramethylpyrazine protects mice retinas against sodium iodate-induced oxidative injury. Mol Vis. 2020 Jun 27;26:494-504. PMID: 32636604; PMCID: PMC7324667. Link
Mice | Full-field ERG intensity series | Immune system dysregulation; AMD, RP, DR
Fernando N, Wong JHC, Das S, Dietrich C, Aggio-Bruce R, Cioanca AV, Wooff Y, Chu-Tan JA, Schumann U, Ngo C, Essex RW, Dorian C, Robertson SA, Man SM, Provis J, Natoli R. MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina. Front Cell Dev Biol. 2020 Jun 26;8:516. doi: 10.3389/fcell.2020.00516. PMID: 32671067; PMCID: PMC7333019.
Mice | Full-field ERG intensity series | Photoreceptor loss and synapse-specific remodeling
Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA. Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors. Cell Rep. 2020 Jun 9;31(10):107730. doi: 10.1016/j.celrep.2020.107730. PMID: 32521255; PMCID: PMC8049532.
Mice | Full-field ERG | Diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa
Weh E, Lutrzykowska Z, Smith A, Hager H, Pawar M, Wubben TJ, Besirli CG. Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress. Cell Death Dis. 2020 Jun 4;11(6):422. doi: 10.1038/s41419-020-2638-2. PMID: 32499533; PMCID: PMC7272456.
Mice | Full-field ERG | Novel capsid, AAV44.9
Boye SL, Choudhury S, Crosson S, Di Pasquale G, Afione S, Mellen R, Makal V, Calabro KR, Fajardo D, Peterson J, Zhang H, Leahy MT, Jennings CK, Chiorini JA, Boyd RF, Boye SE. Novel AAV44.9-Based Vectors Display Exceptional Characteristics for Retinal Gene Therapy. Mol Ther. 2020 Jun 3;28(6):1464-1478. doi: 10.1016/j.ymthe.2020.04.002. Epub 2020 Apr 11. PMID: 32304666; PMCID: PMC7264435.
Mice | Full-field ERG intensity series | Extracellular matrix (ECM) in the CNS; epilepsy, autism, schizophrenia, Alzheimer’s disease
Salido EM, Ramamurthy V. Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. J Neurosci. 2020 May 13;40(20):4059-4072. doi: 10.1523/JNEUROSCI.2994-19.2020. Epub 2020 Apr 7. Erratum in: J Neurosci. 2020 Aug 19;40(34):6660. doi: 10.1523/JNEUROSCI.1846-20.2020. PMID: 32265257; PMCID: PMC7219290.
Mice | Full-field ERG | Neurodegenerative diseases; RP
Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. EBioMedicine. 2020 Feb;52:102636. doi: 10.1016/j.ebiom.2020.102636. Epub 2020 Feb 3. PMID: 32028070; PMCID: PMC7005447.
Mice | Full-field ERG; Flash VEP | Neurotrauma
Naguib S, Bernardo-Colón A, Cencer C, Gandra N, Rex TS. Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma. Neurobiol Dis. 2020 Feb;134:104695. doi: 10.1016/j.nbd.2019.104695. Epub 2019 Nov 25. PMID: 31778813; PMCID: PMC7769189.
Mice | Flash VEP | Sub‐threshold Trauma; TBI
Vest V, Bernardo-Colón A, Watkins D, Kim B, Rex TS. Rapid Repeat Exposure to Subthreshold Trauma Causes Synergistic Axonal Damage and Functional Deficits in the Visual Pathway in a Mouse Model. J Neurotrauma. 2019 May 15;36(10):1646-1654. doi: 10.1089/neu.2018.6046. Epub 2019 Jan 8. PMID: 30451083; PMCID: PMC6531903.
2019
Mice | Full-field ERG intensity series | photoreceptor loss and synapse-specific remodeling
Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019 May 14;27(7):2171-2183.e5. doi: 10.1016/j.celrep.2019.04.065. PMID: 31091454; PMCID: PMC6624172.
2018
Mice | Full-field ERG | Blood-CNS (central nervous system) barrier defects
Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ. Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2691-2705. doi: 10.1161/ATVBAHA.118.311689. PMID: 30354230; PMCID: PMC6221394.
Mice | Flash VEP | Neurotrauma
Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 26;9(11):1097. doi: 10.1038/s41419-018-1061-4. PMID: 30367086; PMCID: PMC6203845.
Mice | Full-field ERG intensity series | Retina Regulatory Molecules; gene identification
Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA. Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 Aug 28;24(9):2506-2519. doi: 10.1016/j.celrep.2018.07.090. PMID: 30157441; PMCID: PMC6170014.
Mice | Full-field ERG intensity series | Protein Misfolding effect on photoreceptors
Brooks C, Snoberger A, Belcastro M, Murphy J, Kisselev OG, Smith DM, Sokolov M. Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. J Neurosci. 2018 Aug 15;38(33):7248-7254. doi: 10.1523/JNEUROSCI.0905-18.2018. Epub 2018 Jul 16. PMID: 30012684; PMCID: PMC6096037.
Mice | Full-field ERG | Diabetic retinopathy; Luteinizing hormone in the human eye
Movsas TZ, Wong KY, Ober MD, Sigler R, Lei ZM, Muthusamy A. Confirmation of Luteinizing Hormone (LH) in Living Human Vitreous and the Effect of LH Receptor Reduction on Murine Electroretinogram. Neuroscience. 2018 Aug 10;385:1-10. doi: 10.1016/j.neuroscience.2018.05.049. Epub 2018 Jun 8. PMID: 29890291; PMCID: PMC6063313.
Mice | Full-field ERG | Photoreceptors
Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21. PMID: 29162627; PMCID: PMC5771314.