The following vision science references are peer-reviewed journal publications for which data were collected using Celeris®, the Diagnosys preclinical visual electrophysiology system. The papers are listed in reverse chronological order. You may suggest adding a paper to this list using the form below.
Rabbit | ERG | Neuroprotection
Kosegawa O, Chukai Y, Shimokawara M, Furukawa N, Yamashita T, Ozaki T. Calpain-1 C2L domain peptide protects retinal photoreceptor cells in rhodopsin P347L transgenic rabbits. Exp Eye Res. 2026 Apr;265:110862. doi: 10.1016/j.exer.2026.110862. Epub 2026 Jan 12. PMID: 41534650.
Mice | VEP | TBI
Wang Y, Yang N, Chen X, Chen X, Ning Y, Yuan R. Impact of blast exposure on visual pathway: Mechanism exploration and novel diagnostic perspectives. PLoS One. 2026 Mar 25;21(3):e0344993. doi: 10.1371/journal.pone.0344993. PMID: 41880282; PMCID: PMC13016288.
Mice | ERG | Coloboma
Wong-Fortunato J, Yang B, Lanoue L, Jacobo Lopez A, Luxardi G, Kasiri N, Minella A, Imai DM, Thomasy SM, Ren Y, Bacha T, Sadegh C, Boobalan E, Brooks BP, Lloyd KK, Leonard BC, Moshiri A. Zfp503 haploinsufficiency causes optic nerve coloboma in mice. Exp Eye Res. 2026 Mar 24;267:110985. doi: 10.1016/j.exer.2026.110985. Epub ahead of print. PMID: 41887347.
Rat | ERG | Ischemia
Takács B, Szilágyi A, Ötvös P, Priksz D, Bombicz M, Szabó AM, Wachal Z, Gesztelyi R, Szabó Z, Szilvássy Z, Juhász B, Varga B. Electroretinographical analysis of the effect of cannabidiol (CBD) in eyes of Zucker diabetic fatty rats. J Cannabis Res. 2026 Mar 17. doi: 10.1186/s42238-026-00421-z. Epub ahead of print. PMID: 41840719.
Mice | ERG | Ferroptosis
Zou Y, Zhang Y, Peng W, Cai Y, Li Y. Ferroptosis mediates retinal damage caused by the combined effects of sleep deprivation and light damage. Free Radic Biol Med. 2026 Mar 7;249:548-562. doi: 10.1016/j.freeradbiomed.2026.03.015. Epub ahead of print. PMID: 41802613.
Mice | ERG | Genetics
Sun K, Zhang L, Liu W, Chen C, He J, Cai J, Jiang X, Yang Y, Yang Z, Zhu X. WTAP mediated m6A methylation modulates retinal photoreceptor function via facilitating of REEP6, PDE6B and RDH12 translation. Sci China Life Sci. 2026 Mar 4. doi: 10.1007/s11427-025-3250-8. Epub ahead of print. PMID: 41796262.
Mice | VEP | Remyelination in MS
Rossi E, Marenna S, Castoldi V, Criscuolo E, Giuliani B, Malacrida C, Clementi N, Comi G, Leocani L. Tracking remyelination in a model of multiple sclerosis: Visual evoked potentials reveal therapeutic effect from brain stimulation and exercise. Exp Neurol. 2026 Mar;397:115565. doi: 10.1016/j.expneurol.2025.115565. Epub 2025 Nov 21. PMID: 41276061.
Mice | ERG | Gene editing
Zhang J, Hołubowicz R, Smidak R, Hu Y, Du SW, Felgner JH, Palczewska G, Rodrigues Menezes C, Risaliti E, Dong Z, Ma X, Shayegan MH, Chen PZ, Xing L, Hołubowicz M, Li B, Liu DR, Felgner PL, Tochtrop GP, Palczewski K. A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina. Nat Commun. 2026 Feb 7;17(1):2479. doi: 10.1038/s41467-026-69077-w. PMID: 41654520; PMCID: PMC12992809.
Mice | ERG and pSTR | NMOSD
Katsura Y, Nakatake-Furuie Y, Onishi S, Kato C, Miyake S, Serizawa K, Nakamura M. Anti-IL-6 Receptor Antibody Suppresses Visual Dysfunction in AQP4 Peptide-Immunized Mice. Transl Vis Sci Technol. 2026 Feb 2;15(2):6. doi: 10.1167/tvst.15.2.6. PMID: 41642041; PMCID: PMC12889182.
Mice | ERG | Alzheimer’s disease
Guidotti L, Lucchesi M, Daghini E, Amato R, Neri G, Corsi F, Marracci S, Gargini C, Borello U, Cammalleri M, Dal Monte M, Casini G. Morpho-Functional Characterization and miRNA Profiling of the Retina in the 5xFAD Murine Model of Alzheimer’s Disease. Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):31. doi: 10.1167/iovs.67.2.31. PMID: 41677387; PMCID: PMC12908725.
Mice | ERG | Degeneration
Torsti T, Tamminen T, Toropainen E, Jalkanen A, Kauppinen A, Kaarniranta K, Forsberg MM. Progressive rod bipolar cell loss, ubiquitin accumulation, and subretinal drusenoid deposits in Cln3Δex7/8 mice: New insights into juvenile neuronal ceroid lipofuscinosis pathogenesis. Exp Eye Res. 2026 Feb;263:110766. doi: 10.1016/j.exer.2025.110766. Epub 2025 Nov 21. PMID: 41274622.
Mice | ERG | Genetics
Hashemi S, Sabbagh SY, Talajia K, Fortenberry J, Tufail S, Turner C, Mukherjee K. CASK hypomorph mice display cone photoreceptor dysfunction. bioRxiv [Preprint]. 2026 Jan 16:2026.01.13.698659. doi: 10.64898/2026.01.13.698659. PMID: 41648531; PMCID: PMC12871234.
Mice | ERG and VEP | Liver-brain-eye axis
Li K, Wang Z, Li S, Wu F, Bai Y, Li S, Zhu C, Ni Z, Zhang S, Wu Y, Tian F, Liu N, Chen T, Ruan C, Zhang Z, Yang Y, Wang Y. Activation of SNr GABA neurons drives liver-brain-eye axis dysfunction in hepatic encephalopathy. iScience. 2026 Jan 16;29(2):114720. doi: 10.1016/j.isci.2026.114720. PMID: 41704772; PMCID: PMC12907090.
Mice | ERG | Modulation
Morgans CW, Haley TL, Ren G, Taylor IAM, Randall KL, Duvoisin RM. The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors. J Neurosci. 2026 Jan 14;46(2):e2277242025. doi: 10.1523/JNEUROSCI.2277-24.2025. PMID: 41371955; PMCID: PMC12809660.
Mice | ERG | Neural function
Jo HC, Pijewska EA, Meleppat RK, Jonnal RS, Moshiri A, Yu Kim D, Zawadzki RJ. Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration. Invest Ophthalmol Vis Sci. 2026 Jan 5;67(1):39. doi: 10.1167/iovs.67.1.39. PMID: 41556589; PMCID: PMC12831139.
Mice | ERG | Gene therapy
Wang Y, Li H, Gao Y, He Q, Cai J, Zou R, Zhu X, Zhang L. FLVCR1 Deficiency Impairs Mitochondrial Homeostasis in Retinal Degeneration: Choline as a Potential Therapy. Clin Exp Ophthalmol. 2026 Jan-Feb;54(1):127-143. doi: 10.1111/ceo.70014. Epub 2025 Oct 22. PMID: 41125404.
Mice | ERG | Photodamage
Chang CH, Liou JC, Hsieh YH, Yang SL, Chang CW, Tsai SY, Yu JY, Lu L, Wang PH, Chen BY. Effects of NGR1 on the Protective Efficacy and Functional Vision Profile of Retinal Photodamage. Int J Med Sci. 2026 Jan 1;23(2):378-388. doi: 10.7150/ijms.122723. PMID: 41583530; PMCID: PMC12825012.
Rat | ERG | Inflammation in geographic atrophy
Zhao S, Voegele F, Tang J, Clark SJ, Tschulakow AV, Julien S. Time Course of Structural, Functional, Complement Changes and Inflammatory Processes in a Sodium Iodate Rat Model of Geographic Atrophy. FASEB J. 2025 Dec 15;39(23):e71307. doi: 10.1096/fj.202502226R. PMID: 41342587; PMCID: PMC12677118.
Mice | ERG | Genetics of retinal ganglion and Amacrine cells
Ueyama T, Yamaguchi K, Aoyama Y, Aoshima K, Onizuka M, Tamagawa T, Kitayama S, Ueyama J, Okamoto K, Mohri H, Shimazawa M. Nox3 expression and function in retinal ganglion cells and Amacrine cells. Cell Mol Life Sci. 2025 Dec 3;83(1):28. doi: 10.1007/s00018-025-05876-6. PMID: 41339603; PMCID: PMC12775227.
Rat | f-VEP | Glaucoma
Wang C, Feng L, Fang W, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W, Xia X. Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma. Int J Surg. 2025 Dec 1;111(12):9147-9165. doi: 10.1097/JS9.0000000000003213. Epub 2025 Aug 20. PMID: 40839015; PMCID: PMC12695214.
Mice | ERG | Diabetic retinopathy
Yokota H, Hayashi H, Nakagami H, Kushiyama A, Hanaguri J, Honjo M, Aihara M, Kurano M, Igarashi K, Kushiyam S, Yamagami S, Nagaoka T. Evidence Supporting Autotaxin as a Potential New Drug Treatment Target in Patients With Advanced Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):49. doi: 10.1167/iovs.66.15.49. PMID: 41400317; PMCID: PMC12720184.
Mice | VEP | Optic nerve regeneration
Shoae-Hassani A, Niknam P, Ahmadirad N, Abri Aghdam K, Javan M, Mirshahi R, Naseripour M, Dehghan S. Encapsulated mesenchymal stem cell-derived exosomes promote optic nerve regeneration and functional recovery in a mouse model of optic nerve crush injury. Life Sci. 2025 Dec 1;382:124013. doi: 10.1016/j.lfs.2025.124013. Epub 2025 Oct 9. PMID: 41067302.
Mice | ERG | Genetics of RP
Li Z, Harichane I, Cronin T, Sahel JA, Léveillard T, Clérin E, Zeitz C, Audo I. Retinal Impairments in Mice Lacking Both Nxnl1 and Nxnl2 Genes. Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):42. doi: 10.1167/iovs.66.15.42. PMID: 41384792; PMCID: PMC12716451.
Mice | ERG | Genetics
Vera E, Henao JC, Cid LP, Sepúlveda FV, Cornejo I. Role of Kir7.1 K+ channel in retinal pigment epithelium probed in a Kir7.1-M125R-expressing mutant mouse. Am J Physiol Cell Physiol. 2025 Dec 1;329(6):C1873-C1879. doi: 10.1152/ajpcell.00690.2025. Epub 2025 Nov 17. PMID: 41247777.
Mice | ERG | Neurodegeneration
Long Z, Zhang J, Feng J, He T. Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury. Exp Eye Res. 2025 Dec;261:110649. doi: 10.1016/j.exer.2025.110649. Epub 2025 Sep 18. PMID: 40975483.
Mice | ERG | Microglia at altitude
Li Y, Han C, Zhang J, Huang S, Zhao X, Zhu J, Niu Q, Yang Y, Zhang W. Microglia activation and migration in retina during acute high-altitude exposure. Exp Eye Res. 2025 Dec;261:110653. doi: 10.1016/j.exer.2025.110653. Epub 2025 Sep 23. PMID: 40998079.
Mice | ERG | Hypoxia
Zheng X, Han C, Ge K, Li Z, Wu P, Yu X, Lu Y, Yang Y, Zhang W. Regulation of the PERK pathway attenuates hypoxia-induced apoptosis in a 661W photoreceptor cell model. Exp Eye Res. 2025 Dec;261:110667. doi: 10.1016/j.exer.2025.110667. Epub 2025 Oct 1. PMID: 41043499.
Rats | ERG and PhNR | Ischemia
Long D, Li Y, Yi S, Lu X. The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury. Sci Rep. 2025 Nov 28;15(1):42769. doi: 10.1038/s41598-025-26957-3. PMID: 41315487; PMCID: PMC12663397.
Mice | ERG | Neurogenesis
Nolasco de Carvalho GV, Spitsbergen JB, Linn DM, Linn CL. An alpha7 nicotinic acetylcholine receptor agonist induces retinal neurogenesis and restores electrophysiological function following blast-induced ocular trauma in adult mice. Front Neurosci. 2025 Nov 26;19:1710987. doi: 10.3389/fnins.2025.1710987. PMID: 41383380; PMCID: PMC12689521.
Rat | ERG | Cell signaling
Mitton KP, Dailey WA, Krikor SQ, Drenser KA. Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells. Int J Mol Sci. 2025 Nov 24;26(23):11340. doi: 10.3390/ijms262311340. PMID: 41373499; PMCID: PMC12692543.
Mice | ERG | Neuroprotection
Li L, Xie H, Zheng M, Li Y, Li S, Liu H, Chen T, Wang Z, Li X, Wang Y, Wang F, Yang A, Xiao X. Kynurenine-mediated redox regulation provides neuroprotection in central retinal artery occlusion. J Transl Med. 2025 Nov 18;23(1):1299. doi: 10.1186/s12967-025-07214-7. PMID: 41254661; PMCID: PMC12625401.
Mice | ERG | Retinal degeneration
Gao F, Zheng Y, Wang T, Zhang M, An Y, Wang Z, Wang B. Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration. Cells. 2025 Nov 17;14(22):1802. doi: 10.3390/cells14221802. PMID: 41294855; PMCID: PMC12650883.
Mice | ERG | Neurodegeneration
Suzumura A, Shimizu H, Yamada K, Ota J, Ito S, Nishiguchi KM, Kaneko H. Retinal Ganglion Cell Senescence Links Diabetes to Retinal Neurodegeneration. Cureus. 2025 Nov 15;17(11):e96926. doi: 10.7759/cureus.96926. PMID: 41409930; PMCID: PMC12706507.
Mice | ERG | Angiogenesis
Jidigam VK, Kirby MB, Gallop J, Shimandle BM, Parsana D, Yu M, Lang RA, Rao S. Endothelial clock regulates retinal angiogenesis and ganglion cell function. Angiogenesis. 2025 Nov 15;29(1):6. doi: 10.1007/s10456-025-10018-4. PMID: 41240167; PMCID: PMC12619741.
Rat | ERG | Ischemia
Chao WW, Chao HW, Peng PH, Lee YT, Chao HM. Retinal Ischemia: Therapeutic Effects and Mechanisms of Paeoniflorin. Int J Mol Sci. 2025 Nov 11;26(22):10924. doi: 10.3390/ijms262210924. PMID: 41303406; PMCID: PMC12652814.
Pigs | ERG | Translational model
Ackermann BC, Skrzypczyk L, Geisweid L, Junker N, Wohlfart S, Uhl P, Auffarth GU, Augustin VA, Hammer M. Increasing dark adaption times and ERG response in landrace pigs – An intraindividual comparison in 20 animals. Exp Eye Res. 2026 Jan;262:110733. doi: 10.1016/j.exer.2025.110733. Epub 2025 Nov 10. PMID: 41224185.
Mice | ERG | Blood-retina-barrier
Furtado J, Zapadka TE, Park H, Boyé K, Demb JB, Eichmann A. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression. Cell Mol Life Sci. 2025 Nov 6;82(1):389. doi: 10.1007/s00018-025-05903-6. PMID: 41196411; PMCID: PMC12592616.
Mice | ERG | TBI
Anvarinia Y, Del Mar NA, Seetharaman ATM, Hossain MS, Prislovsky A, Mandal N, Gangaraju R. The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma. Mil Med. 2025 Nov 1;190(11-12):e2404-e2412. doi: 10.1093/milmed/usaf254. PMID: 40478534; PMCID: PMC12588709.
Rats | ERG | Diabetic neovascularization
Augustine J, Troendle EP, Friedel T, Baldwin C, Byrne EM, Ashraf S, Canning P, McAleese CA, Rollo AG, Barabas P, Lyons TJ, Ulmschneider MB, Stitt AW, Curtis TM. Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease. Diabetologia. 2025 Nov;68(11):2609-2629. doi: 10.1007/s00125-025-06515-2. Epub 2025 Aug 15. PMID: 40815371; PMCID: PMC12534245.
Rat | VEP | Glaucoma
Feng L, Chen Y, Wang C, Zhu W, Zhang C, Huang Q, Song W. Retinal protective effects of zinc-loaded magnesium oxide nanoparticles in a glutamate-excitotoxicity glaucoma model. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025 Oct 28;50(10):1842-1854. Chinese. doi: 10.11817/j.issn.1672-7347.2025.250416. PMID: 41656814; PMCID: PMC12949862.
Mice | ERG | Degeneration
Li M, Wang Y, Li S, Wei Y, Wang G, Du E, Huang Z, Zhang B, Tao Y, Song Z. OGG1 modulates the crosstalk of microglia and Müller cells in degenerative retinas via alleviating inflammatory response and oxidative stress. Exp Eye Res. 2026 Jan;262:110695. doi: 10.1016/j.exer.2025.110695. Epub 2025 Oct 24. PMID: 41855252.
Mice | ERG | Light toxicity in RP
Guarascio R, Ziaka K, Hau KL, Piccolo D, Nieuwenhuis SE, Bakoulina A, Asfahani R, Aguilà M, Athanasiou D, Sefic Svara D, Li Y, Chen R, Cheetham ME. Preventing light-induced toxicity in a new mouse model of sector retinitis pigmentosa caused by Rhodopsin M39R variant. Cell Death Discov. 2025 Oct 21;11(1):477. doi: 10.1038/s41420-025-02769-2. PMID: 41120272; PMCID: PMC12540888.
Mice | ERG | Gene therapy for albinism
Song L, Ren C, Luo M, Su J, Jin X, Fu J, Xu Q, Wu X, Liu F, Ye Q, Hu M, Liu M, Li Q, An Y, Li M, Wang Q, She K, Lu F, Yang Y. Retinal Pigment Epithelium-Targeting Gene Therapy Corrects Ocular Symptoms in Mouse and Rat Models of Oculocutaneous Albinism Type I. MedComm (2020). 2025 Oct 20;6(11):e70433. doi: 10.1002/mco2.70433. PMID: 41122448; PMCID: PMC12536886.
Mice | ERG | Ferroptosis
Shen X, Chen Y, He B, Xi R, Chen J, Wu Y. Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced retinal pigment epithelium degeneration in mice. J Transl Med. 2025 Oct 15;23(1):1103. doi: 10.1186/s12967-025-07195-7. PMID: 41094540; PMCID: PMC12522635.
Mice | ERG | Genetics
Wotton JM, Krebs MP, Sangermano R, Wong JK, Smith C, Willett AM, Howell D, Jones A, Witmeyer C, Lowy JP, McFarland M, Murray SA, Braun RE, Nishina PM, Pierce EA, Place EM, Bujakowska KM, Peachey NS, White JK. Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen. PLoS Genet. 2025 Sep 29;21(9):e1011886. doi: 10.1371/journal.pgen.1011886. PMID: 41021661; PMCID: PMC12503315.
Rat | ERG | Neuroprotection
Yang J, Lewis GP, Hsiang CH, Cho W, Menges S, Ding K, Luna G, Fisher SK, Klassen H. Intravitreal Transplantation of Retinal Progenitor Cells Improves Outcome Measures in a Rat Model of Diabetic Retinopathy. Int J Mol Sci. 2025 Sep 27;26(19):9450. doi: 10.3390/ijms26199450. PMID: 41096718; PMCID: PMC12525025.
Mice | ERG and pSTR | Axial myopia
Insignares S, Kuchtey J, Kuchtey RW. Progressive Ocular Axial Elongation and Retinal Ganglion Cell Degeneration in Mice with Elastic Fiber Disorder. Int J Mol Sci. 2025 Sep 21;26(18):9221. doi: 10.3390/ijms26189221. PMID: 41009782; PMCID: PMC12471019.
Dog | ERG | Hereditary retinopathy
Guareschi BLV, Sallum JMF, Salles MV, de Moraes JGO, Bortolini M, Cray C, Moore BA, da Rosa CC, Montiani-Ferreira F. GUCY2D-Associated Retinopathy: A Comparative Study Between Humans and German Spitz Dogs. Vet Sci. 2025 Sep 11;12(9):879. doi: 10.3390/vetsci12090879. PMID: 41012804; PMCID: PMC12474124.
Mice | ERG | RPE senescence
Zhou T, Yang Z, Ni B, Zhou H, Zhou Y, Xu H, Lin X, Lin S, Yi W, He C, Liu X. Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases. Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):44. doi: 10.1167/iovs.66.12.44. PMID: 40970669; PMCID: PMC12453063.
Mice | ERG | Photoreceptor cilia
Li W, Li Y, Zhou Y, Liu Y, Liu H, Wei X, Sun Z, Han X, Zou X, Li H, Sui R. Exon Skipping Therapy Restores Ciliary Function in USH2A-Related Retinal Degeneration. Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):46. doi: 10.1167/iovs.66.12.46. PMID: 40970667; PMCID: PMC12453064.
Mice | ERG | Photoreceptor degeneration
Liu F, Li Q, Su J, Fu J, Wu X, Xu Q, Ren C, Jin X, Song L, Lu F, Yang Y. RP1 Dual-AAV Gene Therapy Preserves Retinal Structure and Ameliorates Photoreceptor Degeneration in a Murine Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):29. doi: 10.1167/iovs.66.12.29. PMID: 40938072; PMCID: PMC12439500.
Mice | ERG | AMD
Yang J, Bernardo-Colón A, Becerra SP. Lack of Pnpla2 Accelerates Progression of AMD-Like Features in Mice. Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):11. doi: 10.1167/iovs.66.12.11. PMID: 40900080; PMCID: PMC12410252.
Mice | VEP | Visual cortex
Montgomery DP, Bowen DA, Wu J, Bear MF, Gaier ED. Responses to conflicting binocular stimuli in mouse primary visual cortex. bioRxiv [Preprint]. 2025 Sep 1:2024.12.31.630912. doi: 10.1101/2024.12.31.630912. PMID: 39803450; PMCID: PMC11722220.
Mice | ERG | AMD
Francelin C, Qi X, Godoy J, Bicknell BT, Prasad R, Grant MB, Boulton ME. Impact of Donor and Host Age on Systemic Cell Therapy to Treat Age-Related Macular Degeneration. Cells. 2025 Sep 1;14(17):1360. doi: 10.3390/cells14171360. PMID: 40940771; PMCID: PMC12427682.
Rat | VEP | Stem cells
Lu Y, Guo M, Liu Y, Liu H, Liao M, He K, Dong X, Wang T, Wang H, Zhong Y, Yan H. Human induced pluripotent stem cell-derived extracellular vesicles promote neuroprotection effects in rat optic nerve crush model. Exp Eye Res. 2025 Sep;258:110505. doi: 10.1016/j.exer.2025.110505. Epub 2025 Jul 1. PMID: 40609729.
Drosophila | ERG | Infantile cerebellar-retinal degeneration
Buhl E, Garg S, Monaghan M, Preston A, Likeman M, Dare J, Evans J, Taylor LS, Berry I, Urankar K, Spry PGD, Williams C, Taylor RW, Alston CL, Hodge JJL, Majumdar A. Infantile Cerebellar-Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model. Clin Genet. 2025 Sep;108(3):266-278. doi: 10.1111/cge.14745. Epub 2025 Apr 10. PMID: 40210596; PMCID: PMC12319146.
Rabbit | ERG + VEP | Diabetic retinopathy model
Li X, Dong X, Feng D, Hu H, Li B, Liu Z, He W, Huang C, Shi Z, Mei Y. Establishment of a novel alloxan-induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG + VEP. Animal Model Exp Med. 2025 Sep;8(9):1552-1566. doi: 10.1002/ame2.70032. Epub 2025 Jun 19. PMID: 40536048; PMCID: PMC12710098.
Mice | ERG | LCA
Bubis E, Sher I, Ketter-Katz H, Derzane E, Sennlaub F, Rotenstreich Y. Minocycline treatment reduces the activation of mononuclear phagocytes and improves retinal function in a mouse model of Leber congenital amaurosis. Graefes Arch Clin Exp Ophthalmol. 2025 Sep;263(9):2485-2494. doi: 10.1007/s00417-025-06768-y. Epub 2025 Jun 18. PMID: 40528096; PMCID: PMC12513946.
Mice | ERG | Light signaling
Warwick AM, Yu L, Klingeborn M, Travis AM, Parmar VM, Bomze HM, Malek G, Gospe Iii SM. Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival. J Biol Chem. 2025 Sep;301(9):110586. doi: 10.1016/j.jbc.2025.110586. Epub 2025 Aug 12. PMID: 40812421; PMCID: PMC12450623.
Mice | ERG | Stem cell vascular repair
Li Calzi S, Chakraborty D, Hu P, Prasad R, Adu-Rutledge Y, Vieira C, Sheini F, Boulton ME, Yoder MC, Cheng C, Grant MB. Targeting Diabetic Retinopathy with Human iPSC-Derived Vascular Reparative Cells in a Type 2 Diabetes Model. Cells. 2025 Aug 30;14(17):1352. doi: 10.3390/cells14171352. PMID: 40940763; PMCID: PMC12428381.
Mice | ERG | Cilia
Crockett A, Kuzak S, Saravanan T, Guan T, Caspary T, Aliff H, Holmes G, Moakedi F, Ramamurthy V. Ciliary ARL13B Is Essential for Vision and Morphogenesis of Cone Outer Segments. J Neurosci. 2025 Aug 20;45(34):e0752252025. doi: 10.1523/JNEUROSCI.0752-25.2025. PMID: 40721319; PMCID: PMC12369925.
Mice | ERG, PERG, PhNR | Neuroprotection
Gallo Afflitto G, Chou TH, Korsch ML, Aiello F, Adornetto A, Russo R, Bagetta G, Nucci C, Porciatti V. Topical WIN 55 212-2 Confers Long-Term Intraocular Pressure-Independent Neuroprotection in the DBA/2J Mouse Model of Glaucoma. Ophthalmol Sci. 2025 Aug 19;6(1):100918. doi: 10.1016/j.xops.2025.100918. PMID: 41140902; PMCID: PMC12548100.
Mice | mf-ERG | Retinal degeneration
Wang Y, Li S, Zhang C, Li M, Wang K, Wang G, Tao Y, Song Z. AAV-mediated STC-1 expression mitigates neuroinflammation and preserves visual function in degenerative retinopathy. J Transl Med. 2025 Aug 18;23(1):924. doi: 10.1186/s12967-025-06898-1. PMID: 40826460; PMCID: PMC12359868.
Rat | ERG | Microgravity
Liu JS, Yan NQ, Mao YY, Xin C, Mou DP, Gao XX, Guo J, Wang NL, Zhu SQ. Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats. Int J Ophthalmol. 2025 Aug 18;18(8):1409-1425. doi: 10.18240/ijo.2025.08.01. PMID: 40827291; PMCID: PMC12311450.
Mice | ERG | Geographic atrophy
Ridley RB, Tischner BM, Lee J, Walsh E, Massengill MT, Lewin AS, Ildefonso CJ. Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy. Sci Rep. 2025 Aug 17;15(1):30153. doi: 10.1038/s41598-025-15891-z. PMID: 40820160; PMCID: PMC12358612.
Mice | ERG | Axon regeneration
Chen X, Li G. Tumor Necrosis Factor Receptor Superfamily Member 12A Enhances Retinal Ganglion Cell Survival and Promotes Axon Regeneration. FASEB J. 2025 Aug 15;39(15):e70895. doi: 10.1096/fj.202500988RR. PMID: 40747811.
Mice | ERG | Hypoxia
Zheng X, Han C, Yang Y, Zhang W. Inhibition of ER stress mitigates hypobaric hypoxia-induced retinal damage: a simulated high-altitude study. Neuroscience. 2025 Aug 6;580:181-193. doi: 10.1016/j.neuroscience.2025.06.044. Epub 2025 Jun 20. PMID: 40544910.
Mice | ERG | Neovascular disease
Chen C, Yang X, Jiang Z, Wang M, Li X, Huang H, Li M, Liu Y, Liu Z, Deng Y, Zu Y, Dong N, Li C. Dual VEGF-Targeting Strategy Via AAV2-Delivered sFLT-1 and shVEGF for Retinal Neovascularization Therapy. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):37. doi: 10.1167/iovs.66.11.37. PMID: 40810574; PMCID: PMC12366864.
Mice | ERG | Photoreceptors
Nettesheim ER, Rowe AA, Yee T, Alshaikhsalama A, Cepica T, Dutt V, Virani SS, Wickersham G, Mahajan VB, Small KW, Wert KJ. Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):38. doi: 10.1167/iovs.66.11.38. PMID: 40824246; PMCID: PMC12366859.
Mice | ERG | Synapse regulation in diabetic retinal disease
Unlu EK, Marx-Rattner R, Klein KA, Dawson VL, Dawson TM, Sachdeva MM. Differential Expression of the Synapse Regulatory Proteins Neurexins in Early Diabetic Retinal Disease. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):46. doi: 10.1167/iovs.66.11.46. PMID: 40833325; PMCID: PMC12383883.
Mice | ERG | Photoreceptor resilience
Amato R, Canovai A, Melecchi A, De Fenza M, Leone L, Pavone V, D’Alonzo D, Cammalleri M, Dal Monte M. Inhibiting The uPA/uPAR Pathway Affords Photoreceptor Resilience and Preserves Retinal Function in a Mouse Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):29. doi: 10.1167/iovs.66.11.29. PMID: 40793857; PMCID: PMC12364010.
Mice | ERG | AMD
Bora K, Liu CH, Kushwah N, Maurya M, Pavlovich MC, Solt LA, Sun Y, Fu Z, Akula JD, Chen J. Genetic Loss of RORα Impairs Visual Function With Rod Bipolar Cell Degeneration In Mice. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):20. doi: 10.1167/iovs.66.11.20. PMID: 40778701; PMCID: PMC12347186.
Mice | ERG |Macular degeneration
Lu J, He Y, Du Y, Zhao L, Wu P, Shu Q, Peng H, Wang X. Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis. Inflammation. 2025 Aug;48(4):2122-2136. doi: 10.1007/s10753-024-02179-z. Epub 2024 Oct 31. PMID: 39480573.
Mice | µERG | Retinitis pigmentosa
Zhu Y, Peiroten L, Nanda Kumar P, Hottin C, Jiao K, Haq W, Paquet-Durand F. Protein kinase G inhibition preserves photoreceptor viability and function in a new mouse model for autosomal dominant retinitis pigmentosa. Cell Death Dis. 2025 Jul 30;16(1):575. doi: 10.1038/s41419-025-07901-9. PMID: 40738887; PMCID: PMC12311109.
Mice | ERG | Glaucoma
Chen W, Iizuka Y, Mabuchi F, Kashiwagi K. Effects of a ROCK Inhibitor on Retinal Ganglion Cells In Vivo and In Vitro. J Clin Med. 2025 Jul 29;14(15):5344. doi: 10.3390/jcm14155344. PMID: 40806966; PMCID: PMC12347927.
Mice | ERG | Macular edema
Zhang L, Levey J, Abedin M, Jo HN, Odame E, Douglas K, Thoreen E, McPherson SW, Roehrich H, Seshagiri S, Angers S, Chen Z, Junge HJ. C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function. bioRxiv [Preprint]. 2025 Jul 26:2025.07.22.666172. doi: 10.1101/2025.07.22.666172. Update in: JCI Insight. 2025 Oct 14;10(22):e190227. doi: 10.1172/jci.insight.190227. PMID: 40777295; PMCID: PMC12330627.
Mice | ERG | Subretinal injection technique
Cao LY, Chew LA, Finkelstein S, Amason J, Dubey SK, Flynn E, Arshavsky VY, Bowes Rickman C, Alekseev O. Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse. J Vis Exp. 2025 Jul 25;(221):10.3791/68631. doi: 10.3791/68631. PMID: 40788868; PMCID: PMC12591360.
Mice | ERG | Diabetic retinopathy
Gong H, Zuo H, Wu K, Gao X, Lan Y, Zhao L. Systemic and Retinal Protective Effects of Butyrate in Early Type 2 Diabetes via Gut Microbiota-Lipid Metabolism Interaction. Nutrients. 2025 Jul 18;17(14):2363. doi: 10.3390/nu17142363. PMID: 40732988; PMCID: PMC12298851.
Mice | ERG | Alzheimer’s
Lee HM, Kim J, Kim JY, An MJ, Shin GS, Jo AR, Park Y, Kim CH, Hwangbo Y, Lee JH, Hong TK, Lee KH, Rhee S, Kim JW. Retained introns in phototransduction genes of 5xFAD mouse retina suggest vision impairment as an early diagnostic marker for Alzheimer’s disease. Sci Rep. 2025 Jul 15;15(1):25523. doi: 10.1038/s41598-025-11065-z. PMID: 40664927; PMCID: PMC12263821.
Rat | ERG and VEP | Visual electrophysiology indicators
Chen H, Cheng Y, Diao K, Wang Y, An J, Zhang H, Li R, Zhang D, Cheng S, Zhang M, Wang L. The impacts of different eyes, individual differences, and different time points in healthy rats on the variability of visual electrophysiological examination indicators. Front Med (Lausanne). 2025 Jul 8;12:1502787. doi: 10.3389/fmed.2025.1502787. PMID: 40697925; PMCID: PMC12279882.
Mice | ERG c- and d-waves | Genetics of retinitis pigmentosa
Nguyen MN, Chakraborty D, Messinger J, Kraft TW, Sherry DM, Fliesler SJ, Pittler SJ. Dhdds T206A and Dhdds K42E knock-in mouse models of retinitis pigmentosa 59 are phenotypically similar. Dis Model Mech. 2025 Jul 1;18(7):dmm052243. doi: 10.1242/dmm.052243. Epub 2025 Aug 1. PMID: 40574710; PMCID: PMC12352288.
Mice | ERG | Glaucoma
Batsuuri K, Toychiev AH, Viswanathan S, Wohl SG, Srinivas M. Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury. Glia. 2025 Jul;73(7):1398-1419. doi: 10.1002/glia.70013. Epub 2025 Mar 28. PMID: 40156150; PMCID: PMC12121474.
Mice | ERG | Ocular hypertension
Pitale PM, Gibson SE, Keehn CC, Yazdian AT, Shen G, Frankfort BJ. Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice. Aging Dis. 2025 Jun 4. doi: 10.14336/AD.2025.0349. Epub ahead of print. PMID: 40479574.
Mice | ERG | AMD
Lu Z, Liu S, Morales MG, Whitlock A, Ramkumar R, Ramkumar HL. Retinal BMI1 Expression Preserves Photoreceptors in Sodium-Iodate-Induced Oxidative Stress Models. Int J Mol Sci. 2025 Jun 19;26(12):5907. doi: 10.3390/ijms26125907. PMID: 40565365; PMCID: PMC12193584.
Mice | ERG | Photoreceptor apoptosis
Imdad L, Xu S, Meng Y, Bao K, Dong W, Yin X, Tong Y, Zhang W, Ren X, Kong L. Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy. Int J Mol Sci. 2025 Jun 4;26(11):5369. doi: 10.3390/ijms26115369. PMID: 40508179; PMCID: PMC12154564.
Rat | ERG | Diabetic retinopathy
Yang L, Yao Y, Zheng W, Zheng X, Xie M, Huang L. Nitric oxide mediates negative feedback on the TXNIP/NLRP3 inflammasome pathway to prevent retinal neurovascular unit dysfunction in early diabetic retinopathy. Free Radic Biol Med. 2025 Jun;233:279-291. doi: 10.1016/j.freeradbiomed.2025.03.050. Epub 2025 Apr 1. PMID: 40180022.
Mice | ERG | Genetics
Wilder RJ, An AF, Bell BA, Fossett G, Wojciechowski AM, Shpylchak I, Uyhazi KE. Intraretinal variation in disease severity in the Oatrhg mouse model of gyrate atrophy. Exp Eye Res. 2025 Jun;255:110382. doi: 10.1016/j.exer.2025.110382. Epub 2025 Apr 8. PMID: 40210192.
Mice | ERG | Myopia
Mou H, She H, Zhang CJ, Li M, Wang W, Sun SN, Zhang X, Jin ZB. Cathepsin H deficiency leads to myopic phenotype in mice. Exp Eye Res. 2025 Sep;258:110447. doi: 10.1016/j.exer.2025.110447. Epub 2025 May 28. PMID: 40447176.
Rats | ERG | Eye transplantation
Li Y, Komatsu C, He L, Miller MR, Noori J, van der Merwe Y, Ho LC, Rosner IA, Barnett JM, Jabbari K, Wollstein G, Bilonick RA, Fu VLN, Solari MG, Su AA, Chan KC, Schuman JS, Washington KM. Surgical techniques and outcome assessment of a novel vascularized orthotopic rodent whole eye transplantation model. PLoS One. 2025 May 23;20(5):e0311392. doi: 10.1371/journal.pone.0311392. PMID: 40408444; PMCID: PMC12101781.
Mice | ERG | Retinopathy
Wu J, Xie W, Xie Y, Mazhar M, Duan J. Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model. Front Pharmacol. 2025 May 21;16:1573693. doi: 10.3389/fphar.2025.1573693. PMID: 40469974; PMCID: PMC12134759.
Mice | ERG | AMD
Xia F, Wang L, Ji Y, Wang Z, Feng Y, Liao H, Pan X, Li S, Zhu W, Tian J, Tong X, Ma J. Capilliposide A relieved dry age-related macular degeneration through ROS/SIRT1/P53 signaling pathway. Eur J Pharmacol. 2025 May 15;995:177412. doi: 10.1016/j.ejphar.2025.177412. Epub 2025 Feb 19. PMID: 39984014.
Mice | ERG | Rod photoreceptors
Stacks DA, Bocchero U, DeRamus ML, Nguyen MN, Messinger J, Kraft TW, Pittler SJ, Pahlberg J. Selective Knockout of Murine Glutamic Acid-rich Protein 2 (GARP2) Significantly Alters Cellular Dark Noise in Rod Photoreceptors. bioRxiv [Preprint]. 2025 May 14:2025.05.09.653122. doi: 10.1101/2025.05.09.653122. Update in: J Physiol. 2026 Jan;604(1):460-478. doi: 10.1113/JP286548. PMID: 40463092; PMCID: PMC12132428.
Mice | ERG | Neurotransmission
Joachimsthaler A, Hauf K, Armbruster A, Zayit-Soudry S, Naaman E, Perlman I, Leibu R, Kurolap A, Baris Feldman H, Kremers J, Eulenburg V. Changes in glycinergic neurotransmission alter mammalian retinal information processing. Front Mol Neurosci. 2025 May 9;18:1564870. doi: 10.3389/fnmol.2025.1564870. PMID: 40417401; PMCID: PMC12098532.
Mice | ERG | Genetics
Heady L, Rueda R, Segev A, Morton KG, Madabhushi R. Programmed DNA breaks drive chromatin reconfiguration and facilitate transcriptional potentiation at neuronal early response genes. bioRxiv [Preprint]. 2025 May 6:2025.05.06.652469. doi: 10.1101/2025.05.06.652469. PMID: 40654939; PMCID: PMC12248026.
Mice | ERG | Retinal vein occlusion
Zhao Y, Ge Z, Guo T, Liu H, Zhou Y, Chen J, Xu H, Chen Z. Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion. Invest Ophthalmol Vis Sci. 2025 May 1;66(5):2. doi: 10.1167/iovs.66.5.2. PMID: 40310626; PMCID: PMC12054687.
Rat | ERG | Glaucoma
Rak T, Patko E, Szabo E, Vaczy A, Molitor D, Reglodi D, Csutak A, Atlasz T. Combined Herbal Eye Drops Exhibit Neuroprotective and Intraocular Pressure-Reducing Effects in a Glaucoma Rat Model. Antioxidants (Basel). 2025 May 1;14(5):549. doi: 10.3390/antiox14050549. PMID: 40427431; PMCID: PMC12108384.
Mice | ERG | Genetics of retinal degeneration
Liu B, Lang Y, Li Y, Jiang M, Xue M, Jia X, Peng X, Hu Y. Genetic mutation in HSF4 is associated with retinal degeneration in mice. Exp Eye Res. 2025 May;254:110316. doi: 10.1016/j.exer.2025.110316. Epub 2025 Feb 27. PMID: 40023307.
Rats | ERG | Ischemia protection with antioxidation
Chao HW, Chao WW, Chao HM. Catalpol Protects Against Retinal Ischemia Through Antioxidation, Anti-Ischemia, Downregulation of β-Catenin, VEGF, and Angiopoietin-2: In Vitro and In Vivo Studies. Int J Mol Sci. 2025 Apr 24;26(9):4019. doi: 10.3390/ijms26094019. PMID: 40362263; PMCID: PMC12072090.
Mice | ERG | Macular degeneration
He Y, Lu J, Du Y, Zhao L, Gong L, Wu P, Shu Q, Peng H, Wang X. Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40. Sci Rep. 2025 Apr 19;15(1):13514. doi: 10.1038/s41598-025-98174-x. PMID: 40251333; PMCID: PMC12008305.
Rat | ERG | Diabetic retinopathy
Pang X, Bai S, Feng Z, Zhang Y, Hu B, Zhang Y. Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy. Drug Des Devel Ther. 2025 Apr 17;19:2979-2999. doi: 10.2147/DDDT.S501318. PMID: 40260199; PMCID: PMC12011038.
Rat | ERG | Diabetes
Li L, Patko E, Szabo E, Molitor D, Meresz B, Reglodi D, Varga A, Denes D, Dai L, Wang H, Vaczy A, Atlasz T. The Protective Effect of Topical PACAP38 in Retinal Morphology and Function of Type 2 Diabetic Retinopathy. Int J Mol Sci. 2025 Apr 16;26(8):3753. doi: 10.3390/ijms26083753. PMID: 40332399; PMCID: PMC12027713.
Mice | ERG and VEP | Optogenetic gene therapy
Carpentiero E, Hughes S, Rodgers J, Xhaferri N, Biswas S, Gilhooley MJ, Hankins MW, Lindner M. Interaction between native and prosthetic visual responses in optogenetic visual restoration. JCI Insight. 2025 Apr 15;10(11):e190785. doi: 10.1172/jci.insight.190785. PMID: 40232851.
Mice | ERG | Photoreceptor degeneration
Gegnaw ST, Sandu C, Bery A, Ten Brink JB, Milićević N, Jongejan A, Moerland PD, Bergen AA, Felder-Schmittbuhl MP. Circadian clock disruption promotes retinal photoreceptor degeneration. FASEB J. 2025 Apr 15;39(7):e70507. doi: 10.1096/fj.202401967R. PMID: 40171795; PMCID: PMC11962828.
Rat | f-VEP | Neuroprotection
Chen L, Yu Z, Zhu S, Song S, He G, Chi ZL, Wu W. Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):16. doi: 10.1167/iovs.66.4.16. PMID: 40192635; PMCID: PMC11980952.
Mice | ERG | Gene therapy
Wei X, Ma S, Zhou Y, Cui H, Zhang S, Wang D, Fu Y, Li W, Han H, Li Y, Li W, Liu H, Sun Z, Han X, Zou X, Li H, Wang C, Sui R. A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1R213W Mouse Model. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):37. doi: 10.1167/iovs.66.4.37. Erratum in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):29. doi: 10.1167/iovs.66.6.29. PMID: 40232710; PMCID: PMC12007669.
Mice | ERG | Gene therapy
Wei X, Ma S, Zhou Y, Cui H, Zhang S, Wang D, Fu Y, Li W, Han H, Li Y, Li W, Liu H, Sun Z, Han X, Zou X, Li H, Wang C, Sui R. A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1R213W Mouse Model. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):37. doi: 10.1167/iovs.66.4.37. Erratum in: Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):29. doi: 10.1167/iovs.66.6.29. PMID: 40232710; PMCID: PMC12007669.
Mice | Full-field and flicker ERG | FAT3 signaling
Avilés EC, Wang SK, Patel S, Cordero S, Shi S, Lin L, Kefalov VJ, Goodrich LV, Cepko CL, Xue Y. ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. J Gen Physiol. 2025 Mar 3;157(2):e202413642. doi: 10.1085/jgp.202413642. Epub 2025 Feb 4. PMID: 39903280; PMCID: PMC11793021.
Mice | ERG | Blue light ferroptosis
Yang B, Yang K, Chen Y, Li Q, Chen J, Li S, Wu Y. Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium. Cell Mol Biol Lett. 2025 Feb 21;30(1):22. doi: 10.1186/s11658-025-00700-2. PMID: 39984833; PMCID: PMC11846388.
Mice | Full-field ERG | Retinitis pigmentosa
Liu Z, Chen S, Lo CH, Wang Q, Sun Y. All-in-one AAV-mediated Nrl gene inactivation rescues retinal degeneration in Pde6a mice. JCI Insight. 2024 Dec 20;9(24):e178159. doi: 10.1172/jci.insight.178159. PMID: 39499900; PMCID: PMC11665581.
Mice | ERG | Retinal docosahexagonic acid
Sugasini D, Yalagala PCR, Park JC, Ma G, Farooq Z, Baccouche B, Sawant OB, McAnany JJ, Yao X, Kazlauskas A, Layden BT, Subbaiah PV. Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):39. doi: 10.1167/iovs.65.14.39. PMID: 39728692; PMCID: PMC11684127.
Mice | ERG | Mutations in PRPH2
Cavanaugh BL, Milstein ML, Boucher RC, Tan SX, Hanna MW, Seidel A, Frederiksen R, Saunders TL, Sampath AP, Mitton KP, Zhang DQ, Goldberg AFX. A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration. Hum Mol Genet. 2024 Nov 5;33(21):1916-1928. doi: 10.1093/hmg/ddae128. PMID: 39231530; PMCID: PMC11540925.
Mice | ERG | Optic Neuropathy Ccdc13
Wu M, Zhao X, Peng S, Zhang X, Ru J, Xie L, Wen T, Su Y, Xu S, Guo D, Hu J, Lin H, Li T, Liu C. Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):5. doi: 10.1167/iovs.65.13.5. PMID: 39499510; PMCID: PMC11540025.
Mice | Strobe flash ERG | Modeling aging and retinal degeneration
Sturgis J, Singh R, Caron QR, Samuels IS, Shiju TM, Mukkara A, Freedman P, Bonilha VL. Modeling aging and retinal degeneration with mitochondrial DNA mutation burden. Aging Cell. 2024 Nov;23(11):e14282. doi: 10.1111/acel.14282. Epub 2024 Aug 29. PMID: 39210608; PMCID: PMC11561647.
Mice | ERG | Photoreceptors inhibit angiogen
Wang X, Wang T, Kaneko S, Kriukov E, Lam E, Szczepan M, Chen J, Gregg A, Wang X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S, Baranov P, Sun Y. Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos. Angiogenesis. 2024 Aug;27(3):379-395. doi: 10.1007/s10456-024-09912-0. Epub 2024 Mar 14. PMID: 38483712; PMCID: PMC11303108.
Mice | Full-field ERG intensity series | Prohibitin 2 deficiency and Müller glia
Zuo H, Han W, Wu K, Yang H, Song H, Zhang Z, Lai Y, Pan Z, Li W, Zhao L. Prohibitin 2 deficiency in photoreceptors leads to progressive retinal degeneration and facilitated Müller glia engulfing microglia debris. Exp Eye Res. 2024 Jul;244:109935. doi: 10.1016/j.exer.2024.109935. Epub 2024 May 17. PMID: 38763352.
Mice | Full-field ERG intensity series | Micro RNAs
Du SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 Jun;300(6):107344. doi: 10.1016/j.jbc.2024.107344. Epub 2024 May 4. PMID: 38705389; PMCID: PMC11140208.
Mice | Full-field ERG of rod dark adaptation | Cellular retinaldehyde-binding protein
Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 May 28;43(5):114143. doi: 10.1016/j.celrep.2024.114143. Epub 2024 Apr 25. PMID: 38676924; PMCID: PMC11211020.
Mice | PERG, Full-field ERG | Glaucoma
Lin F, Li Y, Wang J, Jardines S, King R, Chrenek MA, Wiggs JL, Boatright JH, Geisert EE. POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells. Sci Rep. 2024 May 2;14(1):10096. doi: 10.1038/s41598-024-60444-5. PMID: 38698014; PMCID: PMC11066091.
Mice | Full-field ERG | Outer retina band pattern
Zeng Y, Gao S, Li Y, Marangoni D, De Silva T, Wong WT, Chew EY, Sun X, Li T, Sieving PA, Qian H. OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy. Bioengineering (Basel). 2024 May 1;11(5):449. doi: 10.3390/bioengineering11050449. PMID: 38790316; PMCID: PMC11118669.
Mice | ERG | Retinitis Pigmentosa
McNamee SM, Chan NP, Akula M, Avola MO, Whalen M, Nystuen K, Singh P, Upadhyay AK, DeAngelis MM, Haider NB. Preclinical dose response study shows NR2E3 can attenuate retinal degeneration in the retinitis pigmentosa mouse model RhoP23H+/. Gene Ther. 2024 May;31(5-6):255-262. doi: 10.1038/s41434-024-00440-6. Epub 2024 Jan 26. PMID: 38273095; PMCID: PMC11090815.
Mice | ERG | Tamoxifen
Lee TT, Bell BA, Anderson BD, Song Y, Dunaief JL. Tamoxifen protects photoreceptors in the sodium iodate model. Exp Eye Res. 2024 May;242:109879. doi: 10.1016/j.exer.2024.109879. Epub 2024 Apr 1. PMID: 38570182; PMCID: PMC11055656.
Mice | ERG | Retinitis pigmentosa
Wang B, Arbuckle RK, Davoli KA, Clinger OD, Brown R, Sahel JA, Chen Y, Pi S. Compensation of inner retina to early-stage photoreceptor degeneration in a RhoP23H/+ mouse model of retinitis pigmentosa. Exp Eye Res. 2024 Mar;240:109826. doi: 10.1016/j.exer.2024.109826. Epub 2024 Feb 8. PMID: 38340947; PMCID: PMC10940204.
Mice | ERG | Pentosan polysulfate sodium
Girardot PE, Zhang X, Zhang N, Donaldson KJ, Chrenek MA, Sellers JT, Feola AJ, Papania J, Nickerson JM, Jain N, Boatright JH. Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice. Invest Ophthalmol Vis Sci. 2024 Feb 1;65(2):28. doi: 10.1167/iovs.65.2.28. Erratum in: Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):47. doi: 10.1167/iovs.65.4.47. PMID: 38381414; PMCID: PMC10893900.
Mice | ERG | Regeneration of visual function
Mokady D, Charish J, Barretto-Burns P, Grisé KN, Coles BLK, Raab S, Ortin-Martinez A, Müller A, Fasching B, Jain P, Drukker M, van der Kooy D, Steger M. Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model. Int J Mol Sci. 2024 Jan 26;25(3):1521. doi: 10.3390/ijms25031521. PMID: 38338800; PMCID: PMC10855388.
Gerbil | Full-field ERG | Cone system physiology
Günter A, Belhadj S, Seeliger MW, Mühlfriedel R. The Mongolian gerbil as an advanced model to study cone system physiology. Front Cell Neurosci. 2024 Jan 25;18:1339282. doi: 10.3389/fncel.2024.1339282. PMID: 38333056; PMCID: PMC10850313.
Rats | Full-field ERG | Exudative age-related macular degeneration (eAMD)
Xu L, Prentice JR, Velez-Montoya R, Sinha A, Barakat MR, Gupta A, Lowenthal R, Khanani AM, Kaiser PK, Heier JS, Jones A, Morgenstern JL, Strong Caldwell A, Mueller N, Quiroz-Mercado H, Huvard M, Olson JL, Bhatt R, Bhandari R. Bispecific VEGF-A and Angiopoietin-2 Antagonist RO-101 Preclinical Efficacy in Model of Neovascular Eye Disease. Ophthalmol Sci. 2024 Jan 18;4(4):100467. doi: 10.1016/j.xops.2024.100467. PMID: 38591047; PMCID: PMC11000112.
Rats | Flash VEP; full-field ERG | Ischemic optic neuropathy
Chien JY, Ciou JW, Yen Y, Huang SP. Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway. Biomed Pharmacother. 2023 Dec 31;169:115861. doi: 10.1016/j.biopha.2023.115861. Epub 2023 Nov 14. PMID: 37972470.
Rats | Full-field ERG, including C-wave | ERG methods
Feola AJ, Allen RS, Chesler KC, Pardue MT. Development of an Automated Electroretinography Analysis Approach. Transl Vis Sci Technol. 2023 Nov 1;12(11):14. doi: 10.1167/tvst.12.11.14. PMID: 37943551; PMCID: PMC10637214.
Mice | mfERG, full-field ERG including C-waves | Leber congenital amaurosis 16 (LCA16); gene editing
Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha K, Pattnaik BR. Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy. J Clin Invest. 2023 Oct 2;133(19):e171356. doi: 10.1172/JCI171356. PMID: 37561581; PMCID: PMC10541187.
Mice | Full-field ERG | Matthew–Wood syndrome (MWS); vitamin A deficiency
Yan Z, Yao Y, Li L, Cai L, Zhang H, Zhang S, Xiao Q, Wang X, Zuo E, Xu C, Wu J, Yang H. Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice. Mol Ther Nucleic Acids. 2023 Aug 7;33:750-761. doi: 10.1016/j.omtn.2023.08.002. PMID: 37621413; PMCID: PMC10445100.
Rats | Full-field ERG | Glaucoma
Nordahl KML, Fedulov V, Holm A, Haanes KA. Intraocular Adeno-Associated Virus-Mediated Transgene Endothelin-1 Delivery to the Rat Eye Induces Functional Changes Indicative of Retinal Ischemia-A Potential Chronic Glaucoma Model. Cells. 2023 Aug 2;12(15):1987. doi: 10.3390/cells12151987. PMID: 37566067; PMCID: PMC10417058.
Mice | Full-field ERG including C-waves | Rod-cone dystrophies (RCDs) and cone-rod dystrophies (CRDs)
García-Llorca A, Ólafsson KH, Sigurdsson AT, Eysteinsson T. Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitfmi/+ Mice. Genes (Basel). 2023 Jul 17;14(7):1458. doi: 10.3390/genes14071458. PMID: 37510362; PMCID: PMC10379086.
Mice | Full-field ERG | Normal aging
Park JC, Persidina O, Balasubramanian G, Nguyen T, Pradeep A, Hetling JR, McAnany JJ. Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography. Sci Rep. 2023 May 31;13(1):8860. doi: 10.1038/s41598-023-35996-7. PMID: 37258636; PMCID: PMC10232421.
Mice | Full-field ERG | Matthew–Wood syndrome (MWS); vitamin A deficiency
Moon J, Zhou G, Jankowsky E, von Lintig J. Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium. PNAS Nexus. 2023 May 19;2(6):pgad167. doi: 10.1093/pnasnexus/pgad167. PMID: 37275262; PMCID: PMC10235913.
Mice | Full-field ERG | ERG methods
Liu S, Yuan F, Xiang M. Comparative analysis of electroretinogram with subdermal and invasive recording methods in mice. Biochem Biophys Res Commun. 2023 May 7;655:118-126. doi: 10.1016/j.bbrc.2023.03.029. Epub 2023 Mar 11. PMID: 36934587.
Mice | Full-field ERG, including C-wave | Excessive exposure to blue light
Chan YJ, Hsiao G, Wan WN, Yang TM, Tsai CH, Kang JJ, Lee YC, Fang TC, Cheng YW, Li CH. Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17. Fluids Barriers CNS. 2023 Apr 24;20(1):31. doi: 10.1186/s12987-023-00430-7. PMID: 37095509; PMCID: PMC10124034.
Rats | Full-field ERG; PhNR | Optic neuropathy; RGC
Pacwa A, Machowicz J, Akhtar S, Rodak P, Liu X, Pietrucha-Dutczak M, Lewin-Kowalik J, Amadio M, Smedowski A. Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells. Front Cell Neurosci. 2023 Feb 17;17:1131356. doi: 10.3389/fncel.2023.1131356. PMID: 36874215; PMCID: PMC9982123.
Mice | PERG | Aging and glaucoma
Li S, Jakobs TC. Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma. Cell Rep. 2022 Dec 27;41(13):111880. doi: 10.1016/j.celrep.2022.111880. PMID: 36577373; PMCID: PMC9847489.
Mice | Full-field ERG | White noise stimuli
Stallwitz N, Joachimsthaler A, Kremers J. Luminance white noise electroretinograms (wnERGs) in mice. Front Neurosci. 2022 Dec 9;16:1075126. doi: 10.3389/fnins.2022.1075126. PMID: 36570850; PMCID: PMC9780692.
Mice | PERG | Trauma, hypoxia, inflammation, glaucoma
Tan Z, Guo Y, Shrestha M, Sun D, Gregory-Ksander M, Jakobs TC. Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109273. doi: 10.1016/j.exer.2022.109273. Epub 2022 Oct 4. PMID: 36206859; PMCID: PMC10970711.
Mice | Full-field ERG | CLN7 Batten disease
Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ. Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics. EBioMedicine. 2022 Nov;85:104314. doi: 10.1016/j.ebiom.2022.104314. Epub 2022 Oct 29. PMID: 36374771; PMCID: PMC9626557.
Rats | Full-field ERG; PhNR | Glaucoma, ischemic optic neuropathy and retinopathy, age-related macular degeneration, and diabetic retinopathy
Olakowska E, Rodak P, Pacwa A, Machowicz J, Machna B, Lewin-Kowalik J, Smedowski A. Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy. Cells. 2022 Sep 29;11(19):3062. doi: 10.3390/cells11193062. PMID: 36231022; PMCID: PMC9564175.
Mice | Full-field ERG | Bardet Biedl Syndrome
Mayer SK, Thomas J, Helms M, Kothapalli A, Cherascu I, Salesevic A, Stalter E, Wang K, Datta P, Searby C, Seo S, Hsu Y, Bhattarai S, Sheffield VC, Drack AV. Progressive retinal degeneration of rods and cones in a Bardet-Biedl syndrome type 10 mouse model. Dis Model Mech. 2022 Sep 1;15(9):dmm049473. doi: 10.1242/dmm.049473. Epub 2022 Sep 20. PMID: 36125046; PMCID: PMC9536196.
Mice | Full-field ERG | Phospholipase D isoforms 1 and 2 in the mammalian brain and retina
Barber CN, Goldschmidt HL, Lilley B, Bygrave AM, Johnson RC, Huganir RL, Zack DJ, Raben DM. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. J Lipid Res. 2022 Aug;63(8):100247. doi: 10.1016/j.jlr.2022.100247. Epub 2022 Jun 25. PMID: 35764123; PMCID: PMC9305353.
Mice | Full-field ERG intensity series; including UV stimulus | Retinitis Pigmentosa
Leinonen H, Lyon DC, Palczewski K, Foik AT. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 Jun 27;9(3):ENEURO.0107-22.2022. doi: 10.1523/ENEURO.0107-22.2022. PMID: 35701168; PMCID: PMC9239850.
Mice | Full-field ERG intensity series | Rod-Cone interactions; lots of ERG data
Lankford CK, Umino Y, Poria D, Kefalov V, Solessio E, Baker SA. Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1. J Neurosci. 2022 May 25;42(21):4231-4249. doi: 10.1523/JNEUROSCI.2271-21.2022. Epub 2022 Apr 18. PMID: 35437278; PMCID: PMC9145265.
Mice | Flash VEP | VEP optimization
Liu S, Xiang K, Lei Q, Qiu S, Xiang M, Jin K. An optimized procedure to record visual evoked potential in mice. Exp Eye Res. 2022 May;218:109011. doi: 10.1016/j.exer.2022.109011. Epub 2022 Mar 1. PMID: 35245512.
Mice | Full-field ERG intensity series; including UV stimulus | Leber congenital amaurosis (LCA)
Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3. PMID: 35383196; PMCID: PMC8983734.
Mice | PERG, full-field ERG, VEP | Glaucoma; RGC
Visuvanathan S, Baker AN, Lagali PS, Coupland SG, Miller G, Hauswirth WW, Tsilfidis C. XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma. Gene Ther. 2022 Apr;29(3-4):147-156. doi: 10.1038/s41434-021-00281-7. Epub 2021 Aug 6. PMID: 34363035.
Mice | PERG | Glaucoma
Zeng H, Dumitrescu AV, Wadkins D, Elwood BW, Gramlich OW, Kuehn MH. Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models. Biomolecules. 2022 Feb 9;12(2):281. doi: 10.3390/biom12020281. PMID: 35204782; PMCID: PMC8961625.
Mice | Full-field ERG | Cone spatiotemporal modifications with cone death
Lee JY, Care RA, Kastner DB, Della Santina L, Dunn FA. Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency. Cell Rep. 2022 Feb 1;38(5):110317. doi: 10.1016/j.celrep.2022.110317. PMID: 35108533; PMCID: PMC8865908.
Mice | Full-field ERG | Paget disease
Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 8;20(1):21. doi: 10.1186/s12967-021-03186-6. PMID: 34998409; PMCID: PMC8742393.
Mice | Full-field ERG intensity series | Diabetes
Saadane A, Lessieur EM, Du Y, Liu H, Kern TS. Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy. PLoS One. 2020 Sep 17;15(9):e0238727. doi: 10.1371/journal.pone.0238727. PMID: 32941450; PMCID: PMC7498040.
Chicks | Full-field ERG intensity series | Glaucoma, retinal ischemia, vascular occlusion, diabetic retinopathy
Heisler-Taylor T, Wan R, Urbanski EG, Hamadmad S, Shah MH, Wilson H, Racine J, Cebulla CM. Multimodal imaging and functional analysis of the chick NMDA retinal damage model. PLoS One. 2021 Sep 7;16(9):e0257148. doi: 10.1371/journal.pone.0257148. PMID: 34492087; PMCID: PMC8423281.
Mice | Full-field ERG | RGC
Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y. Disassembly and rewiring of a mature converging excitatory circuit following injury. Cell Rep. 2021 Aug 3;36(5):109463. doi: 10.1016/j.celrep.2021.109463. PMID: 34348156; PMCID: PMC8381591.
Mice | Full-field ERG intensity series; including UV stimulus | Valosin-containing protein (VCP); musculoskeletal and neurodegenerative conditions
Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30. PMID: 33931547; PMCID: PMC8456514.
Mice | PERG | neurofibromatosis 1 (NF1) cancer
Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. 2021 Jun;594(7862):277-282. doi: 10.1038/s41586-021-03580-6. Epub 2021 May 26. PMID: 34040258; PMCID: PMC8346229.
Mice | Full-field ERG, including C-wave | RPE dysfunction; AMD, RP
Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10;6(9):e146604. doi: 10.1172/jci.insight.146604. PMID: 33784255; PMCID: PMC8262343.
Mice | Full-field ERG | Leber congenital amaurosis (LCA); CRISPR–Cas9
Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 Feb;5(2):169-178. doi: 10.1038/s41551-020-00632-6. Epub 2020 Oct 19. Erratum in: Nat Biomed Eng. 2020 Nov;4(11):1119. doi: 10.1038/s41551-020-00652-2. PMID: 33077938; PMCID: PMC7885272.
Mice | PERG | Glaucoma; RGC
Xiong S, Kumar A, Tian S, Taher EE, Yang E, Kinchington PR, Xia X, Du Y. Stem cell transplantation rescued a primary open-angle glaucoma mouse model. Elife. 2021 Jan 28;10:e63677. doi: 10.7554/eLife.63677. PMID: 33506763; PMCID: PMC7864631.
Guinea pigs | PERG, full-field ERG | RGC function; glaucoma; ONC
Jnawali A, Lin X, Patel NB, Frishman LJ, Ostrin LA. Retinal ganglion cell ablation in guinea pigs. Exp Eye Res. 2021 Jan;202:108339. doi: 10.1016/j.exer.2020.108339. Epub 2020 Oct 27. PMID: 33127343; PMCID: PMC7855240.
Mice | PERG | Ageing; regeneration in vivo; glaucoma; RGC function
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. PMID: 33268865; PMCID: PMC7752134.
Mice | Full-field ERG; pSTR; nSTR | RGC function
Mori S, Kurimoto T, Miki A, Maeda H, Kusuhara S, Nakamura M. Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival. Mol Neurobiol. 2020 Nov;57(11):4530-4548. doi: 10.1007/s12035-020-02030-0. Epub 2020 Aug 4. PMID: 32748371; PMCID: PMC7515957.
Mice | Full-field ERG intensity series | Homeostatic plasticity; RP
Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422. PMID: 32960171; PMCID: PMC7529457.
Mice | Full-field ERG intensity series | dCas9-VPR–mediated transcriptional activation of functionally equivalent genes
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation. Sci Adv. 2020 Aug 19;6(34):eaba5614. doi: 10.1126/sciadv.aba5614. PMID: 32875106; PMCID: PMC7438099.
Mice | PERG, pVEP | Glaucoma; RGC
Harun-Or-Rashid M, Pappenhagen N, Zubricky R, Coughlin L, Jassim AH, Inman DM. MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma. Neurobiol Dis. 2020 Jul;141:104944. doi: 10.1016/j.nbd.2020.104944. Epub 2020 May 15. PMID: 32422282; PMCID: PMC7337244.
Mice | Full-field ERG | AMD, oxidative stress
Huang J, Liu Y, Mao K, Gu Q, Wu X. Tetramethylpyrazine protects mice retinas against sodium iodate-induced oxidative injury. Mol Vis. 2020 Jun 27;26:494-504. PMID: 32636604; PMCID: PMC7324667. Link
Mice | Full-field ERG intensity series | Immune system dysregulation; AMD, RP, DR
Fernando N, Wong JHC, Das S, Dietrich C, Aggio-Bruce R, Cioanca AV, Wooff Y, Chu-Tan JA, Schumann U, Ngo C, Essex RW, Dorian C, Robertson SA, Man SM, Provis J, Natoli R. MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina. Front Cell Dev Biol. 2020 Jun 26;8:516. doi: 10.3389/fcell.2020.00516. PMID: 32671067; PMCID: PMC7333019.
Mice | Full-field ERG intensity series | Photoreceptor loss and synapse-specific remodeling
Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA. Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors. Cell Rep. 2020 Jun 9;31(10):107730. doi: 10.1016/j.celrep.2020.107730. PMID: 32521255; PMCID: PMC8049532.
Mice | Full-field ERG | Diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa
Weh E, Lutrzykowska Z, Smith A, Hager H, Pawar M, Wubben TJ, Besirli CG. Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress. Cell Death Dis. 2020 Jun 4;11(6):422. doi: 10.1038/s41419-020-2638-2. PMID: 32499533; PMCID: PMC7272456.
Mice | Full-field ERG | Novel capsid, AAV44.9
Boye SL, Choudhury S, Crosson S, Di Pasquale G, Afione S, Mellen R, Makal V, Calabro KR, Fajardo D, Peterson J, Zhang H, Leahy MT, Jennings CK, Chiorini JA, Boyd RF, Boye SE. Novel AAV44.9-Based Vectors Display Exceptional Characteristics for Retinal Gene Therapy. Mol Ther. 2020 Jun 3;28(6):1464-1478. doi: 10.1016/j.ymthe.2020.04.002. Epub 2020 Apr 11. PMID: 32304666; PMCID: PMC7264435.
Mice | Full-field ERG | Neurodegenerative diseases; RP
Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. EBioMedicine. 2020 Feb;52:102636. doi: 10.1016/j.ebiom.2020.102636. Epub 2020 Feb 3. PMID: 32028070; PMCID: PMC7005447.
Mice | Full-field ERG; Flash VEP | Neurotrauma
Naguib S, Bernardo-Colón A, Cencer C, Gandra N, Rex TS. Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma. Neurobiol Dis. 2020 Feb;134:104695. doi: 10.1016/j.nbd.2019.104695. Epub 2019 Nov 25. PMID: 31778813; PMCID: PMC7769189.
Mice | Flash VEP | Sub‐threshold Trauma; TBI
Vest V, Bernardo-Colón A, Watkins D, Kim B, Rex TS. Rapid Repeat Exposure to Subthreshold Trauma Causes Synergistic Axonal Damage and Functional Deficits in the Visual Pathway in a Mouse Model. J Neurotrauma. 2019 May 15;36(10):1646-1654. doi: 10.1089/neu.2018.6046. Epub 2019 Jan 8. PMID: 30451083; PMCID: PMC6531903.
Mice | Full-field ERG intensity series | photoreceptor loss and synapse-specific remodeling
Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019 May 14;27(7):2171-2183.e5. doi: 10.1016/j.celrep.2019.04.065. PMID: 31091454; PMCID: PMC6624172.
Mice | Full-field ERG | Blood-CNS (central nervous system) barrier defects
Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ. Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2691-2705. doi: 10.1161/ATVBAHA.118.311689. PMID: 30354230; PMCID: PMC6221394.
Mice | Flash VEP | Neurotrauma
Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 26;9(11):1097. doi: 10.1038/s41419-018-1061-4. PMID: 30367086; PMCID: PMC6203845.
Mice | Full-field ERG intensity series | Retina Regulatory Molecules; gene identification
Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA. Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 Aug 28;24(9):2506-2519. doi: 10.1016/j.celrep.2018.07.090. PMID: 30157441; PMCID: PMC6170014.
Mice | Full-field ERG intensity series | Protein Misfolding effect on photoreceptors
Brooks C, Snoberger A, Belcastro M, Murphy J, Kisselev OG, Smith DM, Sokolov M. Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. J Neurosci. 2018 Aug 15;38(33):7248-7254. doi: 10.1523/JNEUROSCI.0905-18.2018. Epub 2018 Jul 16. PMID: 30012684; PMCID: PMC6096037.
Mice | Full-field ERG | Diabetic retinopathy; Luteinizing hormone in the human eye
Movsas TZ, Wong KY, Ober MD, Sigler R, Lei ZM, Muthusamy A. Confirmation of Luteinizing Hormone (LH) in Living Human Vitreous and the Effect of LH Receptor Reduction on Murine Electroretinogram. Neuroscience. 2018 Aug 10;385:1-10. doi: 10.1016/j.neuroscience.2018.05.049. Epub 2018 Jun 8. PMID: 29890291; PMCID: PMC6063313.
Mice | Full-field ERG | Photoreceptors
Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21. PMID: 29162627; PMCID: PMC5771314.