The following neuroscience references are peer-reviewed journal publications for which data were collected using Celeris®, the Diagnosys preclinical visual electrophysiology system. The papers are listed in reverse chronological order. You may suggest adding a paper to this list using the form below.
Mice | ERG | Alzheimer’s disease
Guidotti L, Lucchesi M, Daghini E, Amato R, Neri G, Corsi F, Marracci S, Gargini C, Borello U, Cammalleri M, Dal Monte M, Casini G. Morpho-Functional Characterization and miRNA Profiling of the Retina in the 5xFAD Murine Model of Alzheimer’s Disease. Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):31. doi: 10.1167/iovs.67.2.31. PMID: 41677387; PMCID: PMC12908725.
Mice | ERG | Neural function
Jo HC, Pijewska EA, Meleppat RK, Jonnal RS, Moshiri A, Yu Kim D, Zawadzki RJ. Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration. Invest Ophthalmol Vis Sci. 2026 Jan 5;67(1):39. doi: 10.1167/iovs.67.1.39. PMID: 41556589; PMCID: PMC12831139.
Mice | VEP | Optic nerve regeneration
Shoae-Hassani A, Niknam P, Ahmadirad N, Abri Aghdam K, Javan M, Mirshahi R, Naseripour M, Dehghan S. Encapsulated mesenchymal stem cell-derived exosomes promote optic nerve regeneration and functional recovery in a mouse model of optic nerve crush injury. Life Sci. 2025 Dec 1;382:124013. doi: 10.1016/j.lfs.2025.124013. Epub 2025 Oct 9. PMID: 41067302.
Mice | ERG | Neurodegeneration
Long Z, Zhang J, Feng J, He T. Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury. Exp Eye Res. 2025 Dec;261:110649. doi: 10.1016/j.exer.2025.110649. Epub 2025 Sep 18. PMID: 40975483.
Mice | ERG | Microglia at altitude
Li Y, Han C, Zhang J, Huang S, Zhao X, Zhu J, Niu Q, Yang Y, Zhang W. Microglia activation and migration in retina during acute high-altitude exposure. Exp Eye Res. 2025 Dec;261:110653. doi: 10.1016/j.exer.2025.110653. Epub 2025 Sep 23. PMID: 40998079.
Mice | ERG | Neurogenesis
Nolasco de Carvalho GV, Spitsbergen JB, Linn DM, Linn CL. An alpha7 nicotinic acetylcholine receptor agonist induces retinal neurogenesis and restores electrophysiological function following blast-induced ocular trauma in adult mice. Front Neurosci. 2025 Nov 26;19:1710987. doi: 10.3389/fnins.2025.1710987. PMID: 41383380; PMCID: PMC12689521.
Mice | ERG | Neuroprotection
Li L, Xie H, Zheng M, Li Y, Li S, Liu H, Chen T, Wang Z, Li X, Wang Y, Wang F, Yang A, Xiao X. Kynurenine-mediated redox regulation provides neuroprotection in central retinal artery occlusion. J Transl Med. 2025 Nov 18;23(1):1299. doi: 10.1186/s12967-025-07214-7. PMID: 41254661; PMCID: PMC12625401.
Mice | ERG | Retinal degeneration
Gao F, Zheng Y, Wang T, Zhang M, An Y, Wang Z, Wang B. Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration. Cells. 2025 Nov 17;14(22):1802. doi: 10.3390/cells14221802. PMID: 41294855; PMCID: PMC12650883.
Mice | ERG | Neurodegeneration
Suzumura A, Shimizu H, Yamada K, Ota J, Ito S, Nishiguchi KM, Kaneko H. Retinal Ganglion Cell Senescence Links Diabetes to Retinal Neurodegeneration. Cureus. 2025 Nov 15;17(11):e96926. doi: 10.7759/cureus.96926. PMID: 41409930; PMCID: PMC12706507.
Mice | ERG | Blood-retina-barrier
Furtado J, Zapadka TE, Park H, Boyé K, Demb JB, Eichmann A. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression. Cell Mol Life Sci. 2025 Nov 6;82(1):389. doi: 10.1007/s00018-025-05903-6. PMID: 41196411; PMCID: PMC12592616.
Rat | ERG | Neuroprotection
Yang J, Lewis GP, Hsiang CH, Cho W, Menges S, Ding K, Luna G, Fisher SK, Klassen H. Intravitreal Transplantation of Retinal Progenitor Cells Improves Outcome Measures in a Rat Model of Diabetic Retinopathy. Int J Mol Sci. 2025 Sep 27;26(19):9450. doi: 10.3390/ijms26199450. PMID: 41096718; PMCID: PMC12525025.
Mice | VEP | Visual cortex
Montgomery DP, Bowen DA, Wu J, Bear MF, Gaier ED. Responses to conflicting binocular stimuli in mouse primary visual cortex. bioRxiv [Preprint]. 2025 Sep 1:2024.12.31.630912. doi: 10.1101/2024.12.31.630912. PMID: 39803450; PMCID: PMC11722220.
Mice | mf-ERG | Retinal degeneration
Wang Y, Li S, Zhang C, Li M, Wang K, Wang G, Tao Y, Song Z. AAV-mediated STC-1 expression mitigates neuroinflammation and preserves visual function in degenerative retinopathy. J Transl Med. 2025 Aug 18;23(1):924. doi: 10.1186/s12967-025-06898-1. PMID: 40826460; PMCID: PMC12359868.
Mice | ERG | Axon regeneration
Chen X, Li G. Tumor Necrosis Factor Receptor Superfamily Member 12A Enhances Retinal Ganglion Cell Survival and Promotes Axon Regeneration. FASEB J. 2025 Aug 15;39(15):e70895. doi: 10.1096/fj.202500988RR. PMID: 40747811.
Mice | ERG | Photoreceptors
Nettesheim ER, Rowe AA, Yee T, Alshaikhsalama A, Cepica T, Dutt V, Virani SS, Wickersham G, Mahajan VB, Small KW, Wert KJ. Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):38. doi: 10.1167/iovs.66.11.38. PMID: 40824246; PMCID: PMC12366859.
Mice | ERG | Synapse regulation in diabetic retinal disease
Unlu EK, Marx-Rattner R, Klein KA, Dawson VL, Dawson TM, Sachdeva MM. Differential Expression of the Synapse Regulatory Proteins Neurexins in Early Diabetic Retinal Disease. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):46. doi: 10.1167/iovs.66.11.46. PMID: 40833325; PMCID: PMC12383883.
Mice | ERG | Alzheimer’s
Lee HM, Kim J, Kim JY, An MJ, Shin GS, Jo AR, Park Y, Kim CH, Hwangbo Y, Lee JH, Hong TK, Lee KH, Rhee S, Kim JW. Retained introns in phototransduction genes of 5xFAD mouse retina suggest vision impairment as an early diagnostic marker for Alzheimer’s disease. Sci Rep. 2025 Jul 15;15(1):25523. doi: 10.1038/s41598-025-11065-z. PMID: 40664927; PMCID: PMC12263821.
Mice | ERG | Neurotransmission
Joachimsthaler A, Hauf K, Armbruster A, Zayit-Soudry S, Naaman E, Perlman I, Leibu R, Kurolap A, Baris Feldman H, Kremers J, Eulenburg V. Changes in glycinergic neurotransmission alter mammalian retinal information processing. Front Mol Neurosci. 2025 May 9;18:1564870. doi: 10.3389/fnmol.2025.1564870. PMID: 40417401; PMCID: PMC12098532.
Mice | ERG and VEP | Optogenetic gene therapy
Carpentiero E, Hughes S, Rodgers J, Xhaferri N, Biswas S, Gilhooley MJ, Hankins MW, Lindner M. Interaction between native and prosthetic visual responses in optogenetic visual restoration. JCI Insight. 2025 Apr 15;10(11):e190785. doi: 10.1172/jci.insight.190785. PMID: 40232851.
Mice | ERG | Photoreceptor degeneration
Gegnaw ST, Sandu C, Bery A, Ten Brink JB, Milićević N, Jongejan A, Moerland PD, Bergen AA, Felder-Schmittbuhl MP. Circadian clock disruption promotes retinal photoreceptor degeneration. FASEB J. 2025 Apr 15;39(7):e70507. doi: 10.1096/fj.202401967R. PMID: 40171795; PMCID: PMC11962828.
Rat | f-VEP | Neuroprotection
Chen L, Yu Z, Zhu S, Song S, He G, Chi ZL, Wu W. Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):16. doi: 10.1167/iovs.66.4.16. PMID: 40192635; PMCID: PMC11980952.
Rats | VEP | Parkinson’s disease
Østergaard FG. Knocking out the LRRK2 gene increases sensitivity to wavelength information in rats. Sci Rep. 2024 Feb 29;14(1):4984. doi: 10.1038/s41598-024-55350-9. PMID: 38424139; PMCID: PMC10904730.
Mice | ERG | Optic Neuropathy Ccdc13
Wu M, Zhao X, Peng S, Zhang X, Ru J, Xie L, Wen T, Su Y, Xu S, Guo D, Hu J, Lin H, Li T, Liu C. Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):5. doi: 10.1167/iovs.65.13.5. PMID: 39499510; PMCID: PMC11540025.
Mice | Strobe flash ERG | Modeling aging and retinal degeneration
Sturgis J, Singh R, Caron QR, Samuels IS, Shiju TM, Mukkara A, Freedman P, Bonilha VL. Modeling aging and retinal degeneration with mitochondrial DNA mutation burden. Aging Cell. 2024 Nov;23(11):e14282. doi: 10.1111/acel.14282. Epub 2024 Aug 29. PMID: 39210608; PMCID: PMC11561647.
Mice | ERG | Photoreceptors inhibit angiogen
Wang X, Wang T, Kaneko S, Kriukov E, Lam E, Szczepan M, Chen J, Gregg A, Wang X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S, Baranov P, Sun Y. Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos. Angiogenesis. 2024 Aug;27(3):379-395. doi: 10.1007/s10456-024-09912-0. Epub 2024 Mar 14. PMID: 38483712; PMCID: PMC11303108.
Mice | Full-field ERG intensity series | Prohibitin 2 deficiency and Müller glia
Zuo H, Han W, Wu K, Yang H, Song H, Zhang Z, Lai Y, Pan Z, Li W, Zhao L. Prohibitin 2 deficiency in photoreceptors leads to progressive retinal degeneration and facilitated Müller glia engulfing microglia debris. Exp Eye Res. 2024 Jul;244:109935. doi: 10.1016/j.exer.2024.109935. Epub 2024 May 17. PMID: 38763352.
Mice | Full-field ERG of rod dark adaptation | Cellular retinaldehyde-binding protein
Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 May 28;43(5):114143. doi: 10.1016/j.celrep.2024.114143. Epub 2024 Apr 25. PMID: 38676924; PMCID: PMC11211020.
Mice | Full-field ERG | Outer retina band pattern
Zeng Y, Gao S, Li Y, Marangoni D, De Silva T, Wong WT, Chew EY, Sun X, Li T, Sieving PA, Qian H. OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy. Bioengineering (Basel). 2024 May 1;11(5):449. doi: 10.3390/bioengineering11050449. PMID: 38790316; PMCID: PMC11118669.
Mice | ERG | Regeneration of visual function
Mokady D, Charish J, Barretto-Burns P, Grisé KN, Coles BLK, Raab S, Ortin-Martinez A, Müller A, Fasching B, Jain P, Drukker M, van der Kooy D, Steger M. Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model. Int J Mol Sci. 2024 Jan 26;25(3):1521. doi: 10.3390/ijms25031521. PMID: 38338800; PMCID: PMC10855388.
Gerbils | Full-field ERG | Cone system physiology
Günter A, Belhadj S, Seeliger MW, Mühlfriedel R. The Mongolian gerbil as an advanced model to study cone system physiology. Front Cell Neurosci. 2024 Jan 25;18:1339282. doi: 10.3389/fncel.2024.1339282. PMID: 38333056; PMCID: PMC10850313.
Rats | Full-field ERG | Exudative age-related macular degeneration (eAMD)
Xu L, Prentice JR, Velez-Montoya R, Sinha A, Barakat MR, Gupta A, Lowenthal R, Khanani AM, Kaiser PK, Heier JS, Jones A, Morgenstern JL, Strong Caldwell A, Mueller N, Quiroz-Mercado H, Huvard M, Olson JL, Bhatt R, Bhandari R. Bispecific VEGF-A and Angiopoietin-2 Antagonist RO-101 Preclinical Efficacy in Model of Neovascular Eye Disease. Ophthalmol Sci. 2024 Jan 18;4(4):100467. doi: 10.1016/j.xops.2024.100467. PMID: 38591047; PMCID: PMC11000112.
Mice | ERG | Neurodegenerative diseases
Gao J, Leinonen H, Wang EJ, Ding M, Perry G, Palczewski K, Wang X. Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice. J Alzheimers Dis. 2024;97(2):927-937. doi: 10.3233/JAD-231102. PMID: 38143367; PMCID: PMC11174142.
Mouse | ERG | Alzheimer’s disease
Di Paolo M, Corsi F, Cerri C, Bisti S, Piano I, Gargini C. A Window to the Brain: The Retina to Monitor the Progression and Efficacy of Saffron Repron® Pre-Treatment in an LPS Model of Neuroinflammation and Memory Impairment. Pharmaceuticals (Basel). 2023 Sep 15;16(9):1307. doi: 10.3390/ph16091307. PMID: 37765115; PMCID: PMC10536337.
Rats | Flash VEP; full-field ERG | Ischemic optic neuropathy
Chien JY, Ciou JW, Yen Y, Huang SP. Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway. Biomed Pharmacother. 2023 Dec 31;169:115861. doi: 10.1016/j.biopha.2023.115861. Epub 2023 Nov 14. PMID: 37972470.
Rats | Full-field ERG, including C-wave | ERG methods
Feola AJ, Allen RS, Chesler KC, Pardue MT. Development of an Automated Electroretinography Analysis Approach. Transl Vis Sci Technol. 2023 Nov 1;12(11):14. doi: 10.1167/tvst.12.11.14. PMID: 37943551; PMCID: PMC10637214.
Mice | Full-field ERG intensity series | Alzheimer disease
Sugasini D, Park JC, McAnany JJ, Kim TH, Ma G, Yao X, Antharavally B, Oroskar A, Oroskar AA, Layden BT, Subbaiah PV. Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA. Sci Rep. 2023 Jun 6;13(1):9179. doi: 10.1038/s41598-023-36268-0. PMID: 37280266; PMCID: PMC10244360.
Mice | Full-field ERG | Normal aging
Park JC, Persidina O, Balasubramanian G, Nguyen T, Pradeep A, Hetling JR, McAnany JJ. Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography. Sci Rep. 2023 May 31;13(1):8860. doi: 10.1038/s41598-023-35996-7. PMID: 37258636; PMCID: PMC10232421.
Mice | Full-field ERG | ERG methods
Liu S, Yuan F, Xiang M. Comparative analysis of electroretinogram with subdermal and invasive recording methods in mice. Biochem Biophys Res Commun. 2023 May 7;655:118-126. doi: 10.1016/j.bbrc.2023.03.029. Epub 2023 Mar 11. PMID: 36934587.
Mice | Full-field ERG, including C-wave | Excessive exposure to blue light
Chan YJ, Hsiao G, Wan WN, Yang TM, Tsai CH, Kang JJ, Lee YC, Fang TC, Cheng YW, Li CH. Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17. Fluids Barriers CNS. 2023 Apr 24;20(1):31. doi: 10.1186/s12987-023-00430-7. PMID: 37095509; PMCID: PMC10124034.
Rats | Full-field ERG; PhNR | Optic neuropathy; RGC
Pacwa A, Machowicz J, Akhtar S, Rodak P, Liu X, Pietrucha-Dutczak M, Lewin-Kowalik J, Amadio M, Smedowski A. Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells. Front Cell Neurosci. 2023 Feb 17;17:1131356. doi: 10.3389/fncel.2023.1131356. PMID: 36874215; PMCID: PMC9982123.
Mice | Full-field ERG, flash VEP, PhNR | Alzheimer’s disease and frontotemporal dementia
Parka A, Volbracht C, Hall B, Bastlund JF, Nedergaard M, Laursen B, Botta P, Sotty F. Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model. J Alzheimers Dis. 2023;93(1):247-262. doi: 10.3233/JAD-220964. PMID: 37005884.
Mice | PERG | Aging and glaucoma
Li S, Jakobs TC. Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma. Cell Rep. 2022 Dec 27;41(13):111880. doi: 10.1016/j.celrep.2022.111880. PMID: 36577373; PMCID: PMC9847489.
Mice | PERG | Trauma, hypoxia, inflammation, glaucoma
Tan Z, Guo Y, Shrestha M, Sun D, Gregory-Ksander M, Jakobs TC. Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109273. doi: 10.1016/j.exer.2022.109273. Epub 2022 Oct 4. PMID: 36206859; PMCID: PMC10970711.
Rats | Full-field ERG; PhNR | Retinal conductivity
Olakowska E, Rodak P, Pacwa A, Machowicz J, Machna B, Lewin-Kowalik J, Smedowski A. Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy. Cells. 2022 Sep 29;11(19):3062. doi: 10.3390/cells11193062. PMID: 36231022; PMCID: PMC9564175.
Mice | Full-field ERG | Phospholipase D isoforms 1 and 2 in the mammalian brain and retina
Barber CN, Goldschmidt HL, Lilley B, Bygrave AM, Johnson RC, Huganir RL, Zack DJ, Raben DM. Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. J Lipid Res. 2022 Aug;63(8):100247. doi: 10.1016/j.jlr.2022.100247. Epub 2022 Jun 25. PMID: 35764123; PMCID: PMC9305353.
Mice | Full-field ERG | Spinocerebellar ataxia type 3
Toulis V, Casaroli-Marano R, Camós-Carreras A, Figueras-Roca M, Sánchez-Dalmau B, Muñoz E, Ashraf NS, Ferreira AF, Khan N, Marfany G, Costa MDC. Altered retinal structure and function in Spinocerebellar ataxia type 3. Neurobiol Dis. 2022 Aug;170:105774. doi: 10.1016/j.nbd.2022.105774. Epub 2022 May 21. PMID: 35605759.
Mice | Full-field ERG intensity series | Rod-Cone interactions; lots of ERG data
Lankford CK, Umino Y, Poria D, Kefalov V, Solessio E, Baker SA. Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1. J Neurosci. 2022 May 25;42(21):4231-4249. doi: 10.1523/JNEUROSCI.2271-21.2022. Epub 2022 Apr 18. PMID: 35437278; PMCID: PMC9145265.
Mice | Flash VEP | VEP optimization
Liu S, Xiang K, Lei Q, Qiu S, Xiang M, Jin K. An optimized procedure to record visual evoked potential in mice. Exp Eye Res. 2022 May;218:109011. doi: 10.1016/j.exer.2022.109011. Epub 2022 Mar 1. PMID: 35245512.
Mice | ERG | Huntington’s disease
Helmlinger D, Yvert G, Picaud S, Merienne K, Sahel J, Mandel JL, Devys D. Progressive retinal degeneration and dysfunction in R6 Huntington’s disease mice. Hum Mol Genet. 2002 Dec 15;11(26):3351-9. doi: 10.1093/hmg/11.26.3351. PMID: 12471061.
Mice | Full-field ERG intensity series; including UV stimulus | Leber congenital amaurosis (LCA)
Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3. PMID: 35383196; PMCID: PMC8983734.
Mice | Full-field ERG | Cone spatiotemporal modifications with cone death
Lee JY, Care RA, Kastner DB, Della Santina L, Dunn FA. Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency. Cell Rep. 2022 Feb 1;38(5):110317. doi: 10.1016/j.celrep.2022.110317. PMID: 35108533; PMCID: PMC8865908.
Mice | PERG, full-field ERG | Alzheimer’s disease
Frame G, Schuller A, Smith MA, Crish SD, Dengler-Crish CM. Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer’s Disease Mice. J Alzheimers Dis. 2022;88(2):471-492. doi: 10.3233/JAD-220016. PMID: 35599482; PMCID: PMC9398084.
Mice | Full-field ERG | Bardet Biedl Syndrome
Sara K. Mayer, Jacintha Thomas, Megan Helms, Aishwarya Kothapalli, Ioana Cherascu, Adisa Salesevic, Elliot Stalter, Kai Wang, Poppy Datta, Charles Searby, Seongjin Seo, Ying Hsu, Sajag Bhattarai, Val C. Sheffield, Arlene V. Drack. Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones. bioRxiv 2022.01.19.476952; doi: 10.1101/2022.01.19.476952
Mice | Full-field ERG | RGC; Circuit rewiring
Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y. Disassembly and rewiring of a mature converging excitatory circuit following injury. Cell Rep. 2021 Aug 3;36(5):109463. doi: 10.1016/j.celrep.2021.109463. PMID: 34348156; PMCID: PMC8381591.
Mice | Full-field ERG intensity series; including UV stimulus | Valosin-containing protein (VCP); musculoskeletal and neurodegenerative conditions
Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30. PMID: 33931547; PMCID: PMC8456514.
Mice | Full-field ERG, including C-wave | Role of RPE; Retinal physiology
Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10;6(9):e146604. doi: 10.1172/jci.insight.146604. PMID: 33784255; PMCID: PMC8262343.
Mice | PERG | Stem Cell; RGC
Xiong S, Kumar A, Tian S, Taher EE, Yang E, Kinchington PR, Xia X, Du Y. Stem cell transplantation rescued a primary open-angle glaucoma mouse model. Elife. 2021 Jan 28;10:e63677. doi: 10.7554/eLife.63677. PMID: 33506763; PMCID: PMC7864631.
Mice | Full-field ERG; STR | Alzheimer’s disease
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, Moons L, De Groef L. The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research. Acta Neuropathol Commun. 2021 Jan 6;9(1):6. doi: 10.1186/s40478-020-01102-5. PMID: 33407903; PMCID: PMC7788955.
Mice | ERG and PhNR | Alzheimer’s disease
McAnany JJ, Matei N, Chen YF, Liu K, Park JC, Shahidi M. Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease. Sci Rep. 2021 Mar 1;11(1):4824. doi: 10.1038/s41598-021-84318-2. PMID: 33649406; PMCID: PMC7921657.
Mice | VEP | Multiple Sclerosis
Sekyi MT, Lauderdale K, Atkinson KC, Golestany B, Karim H, Feri M, Soto JS, Diaz C, Kim SH, Cilluffo M, Nusinowitz S, Katzenellenbogen JA, Tiwari-Woodruff SK. Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis. Brain Pathol. 2021 Mar;31(2):312-332. doi: 10.1111/bpa.12930. Epub 2021 Jan 29. PMID: 33368801; PMCID: PMC8018057.
Mice | PERG | Ageing; regeneration in vivo; glaucoma; RGC function
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. PMID: 33268865; PMCID: PMC7752134.
Mice | Full-field ERG; pSTR; nSTR | RGC function
Mori S, Kurimoto T, Miki A, Maeda H, Kusuhara S, Nakamura M. Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival. Mol Neurobiol. 2020 Nov;57(11):4530-4548. doi: 10.1007/s12035-020-02030-0. Epub 2020 Aug 4. PMID: 32748371; PMCID: PMC7515957.
Mice | Full-field ERG intensity series | Homeostatic plasticity; RP
Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422. PMID: 32960171; PMCID: PMC7529457.
Mice | Full-field ERG intensity series | Photoreceptor loss and synapse-specific remodeling
Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA. Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors. Cell Rep. 2020 Jun 9;31(10):107730. doi: 10.1016/j.celrep.2020.107730. PMID: 32521255; PMCID: PMC8049532.
Mice | Full-field ERG intensity series | Extracellular matrix (ECM) in the CNS; epilepsy, autism, schizophrenia, Alzheimer’s disease
Salido EM, Ramamurthy V. Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. J Neurosci. 2020 May 13;40(20):4059-4072. doi: 10.1523/JNEUROSCI.2994-19.2020. Epub 2020 Apr 7. Erratum in: J Neurosci. 2020 Aug 19;40(34):6660. doi: 10.1523/JNEUROSCI.1846-20.2020. PMID: 32265257; PMCID: PMC7219290.
Mice | Full-field ERG | Neurodegenerative diseases; RP
Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. EBioMedicine. 2020 Feb;52:102636. doi: 10.1016/j.ebiom.2020.102636. Epub 2020 Feb 3. PMID: 32028070; PMCID: PMC7005447.
Mice | Full-field ERG; Flash VEP | Neurotrauma
Naguib S, Bernardo-Colón A, Cencer C, Gandra N, Rex TS. Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma. Neurobiol Dis. 2020 Feb;134:104695. doi: 10.1016/j.nbd.2019.104695. Epub 2019 Nov 25. PMID: 31778813; PMCID: PMC7769189.
Mice | Flash VEP | Sub‐threshold Trauma; TBI
Vest V, Bernardo-Colón A, Watkins D, Kim B, Rex TS. Rapid Repeat Exposure to Subthreshold Trauma Causes Synergistic Axonal Damage and Functional Deficits in the Visual Pathway in a Mouse Model. J Neurotrauma. 2019 May 15;36(10):1646-1654. doi: 10.1089/neu.2018.6046. Epub 2019 Jan 8. PMID: 30451083; PMCID: PMC6531903.
Cats | VEP | Remyelination
Heidari M, Radcliff AB, McLellan GJ, Ver Hoeve JN, Chan K, Kiland JA, Keuler NS, August BK, Sebo D, Field AS, Duncan ID. Evoked potentials as a biomarker of remyelination. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):27074-27083. doi: 10.1073/pnas.1906358116. Epub 2019 Dec 16. PMID: 31843913; PMCID: PMC6936696.
Mice | Full-field ERG intensity series | photoreceptor loss and synapse-specific remodeling
Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Rep. 2019 May 14;27(7):2171-2183.e5. doi: 10.1016/j.celrep.2019.04.065. PMID: 31091454; PMCID: PMC6624172.
Mice | ERG | Alzheimer’s disease
Georgevsky D, Retsas S, Raoufi N, Shimoni O, Golzan SM. A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease. Transl Neurodegener. 2019 Oct 1;8:30. doi: 10.1186/s40035-019-0170-z. PMID: 31592131; PMCID: PMC6774218.
Mice | Flash VEP | Neurotrauma
Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 26;9(11):1097. doi: 10.1038/s41419-018-1061-4. PMID: 30367086; PMCID: PMC6203845.
Mice | Full-field ERG | Photoreceptors
Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21. PMID: 29162627; PMCID: PMC5771314.
Rats | VEP | Multiple Sclerosis
Baradaran S, Hajizadeh Moghaddam A, Ghasemi-Kasman M. Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm. Life Sci. 2018 Aug 15;207:471-479. doi: 10.1016/j.lfs.2018.07.001. Epub 2018 Jul 3. PMID: 30056861.